{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:18Z","timestamp":1747185078589,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and objectives<\/jats:title><jats:p>Repeated joint bleeding in haemophilia patients may lead to haemophilic arthropathy with marked inflammation and synovitis. This study investigated the potential of <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\u2010computed tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT) as a novel diagnostic method for haemophilic arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We recruited 20 adult haemophilia patients who reported history of hemarthroses in the shoulder, elbow, hip, knee, or ankle joints. All joints were assessed by power Doppler ultrasonography and radiography, and graded by hyperaemia score and Pettersson score, respectively. Joint pain was evaluated by visual analogue score (VAS). Range of motion (ROM), Haemophilia Joint Health Score (HJHS) and annual joint bleeding rate (AJBR) were recorded. Finally, all participants had whole\u2010body <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT, and maximum standardized uptake value (SUVmax) of the joints being studied was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients had severe haemophilia, and seven had moderate haemophilia. The mean age was 36 years. PET SUVmax showed significant correlations with VAS, ROM, Pettersson score, hyperaemia score, HJHS score and AJBR in all large joints except hip. Joints with pain, hyperaemia and radiographic changes were found to have higher SUVmax than those without these features. Using Youden's index, the optimal cut\u2010off value for early radiographical arthropathy was found to be between 1.9 and 2.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates that <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT imaging correlated well with various conventional diagnostic techniques. It also demonstrated high sensitivity and specificity for early radiographic arthropathy. <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT imaging may quantitatively evaluate disease activity of most large joints in a single examination and help detect early haemophilic arthropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14736","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T17:00:13Z","timestamp":1672333213000},"page":"640-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<sup>18<\/sup>F\u2010FDG PET\/CT imaging for haemophilic arthropathy compared with clinical, radiological and power Doppler sonographic characteristics of 20 haemophilia patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7683-6010","authenticated-orcid":false,"given":"Tsung\u2010Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"},{"name":"Haemophilia Care and Research Center Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and PET center Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru\u2010Yu","family":"Pan","sequence":"additional","affiliation":[{"name":"Haemophilia Care and Research Center Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"},{"name":"Department of Orthopaedics Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Nan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Haemophilia Care and Research Center Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"},{"name":"Department of Paediatrics Tung's Taichung Metrohabor Hospital  Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Tsan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-7723","authenticated-orcid":false,"given":"Yeu\u2010Chin","family":"Chen","sequence":"additional","affiliation":[{"name":"Haemophilia Care and Research Center Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan ROC"},{"name":"Division of Haematology\/Oncology Department of Internal Medicine Tri\u2010Service General Hospital School of Medicine National Defense Medical Center  Taipei Taiwan 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