{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:08:13Z","timestamp":1789495693262,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pain is a major issue in people with haemophilia (PwH). Few studies comprehensively assessed pain in PwH using a biopsychosocial framework and studies in mild PwH are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess pain prevalence, pain interference and their relationship with health\u2010related quality of life (HR\u2010QoL) in male adults with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey was initiated by the Belgian national member organisation. Pain in the last 24\u00a0h, pain severity (BPI\u2010PS) and pain interference (BPI\u2010PI) scores were obtained with the Brief Pain Inventory short\u2010form (BPI). HR\u2010QoL was evaluated with the EQ\u20105D\u20103L, giving the health utility index (EQ\u2010HUI). Associations between EQ\u2010HUI, BPI\u2010PS and BPI\u2010PI were analysed using Pearson's correlation test. A multiple regression analysed the relationship between HR\u2010QoL and BPI\u2010PS, with age and haemophilia severity as confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within 185 respondents (97, 31 and 57 respectively severe, moderate and mild PwH), 67% (118\/177) reported pain. In severe, moderate and mild PwH, respectively 86% (79\/92), 71% (22\/31) and 32% (17\/54) reported pain. Median [IQR] BPI\u2010PS, BPI\u2010PI and EQ\u2010HUI scores were respectively 1.5 [.0; 4.0], 1.6 [.0; 3.6] and .81 [.69; 1.00]. PwH reported pain interference with general activity (56% (99\/176)), psychosocial factors such as mood (53% (93\/175)), and sleep (51% (90\/177)). Moderate correlations were found between EQ\u2010HUI, BPI\u2010PS and BPI\u2010PI. After adjusting for age and haemophilia severity, BPI\u2010PS explained 14% of HR\u2010QoL variance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pain is a major issue amongst PwH, including people with mild haemophilia. Pain interferes with activities, emotions, sleep and HR\u2010QoL, arguing for a comprehensive biopsychosocial approach of pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14747","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T21:04:28Z","timestamp":1674162268000},"page":"521-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pain interferes with daily activities, emotions and sleep in adults with severe, moderate and mild haemophilia: A national cross\u2010sectional survey"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-7112","authenticated-orcid":false,"given":"Val\u00e9rie\u2010Anne","family":"Chantrain","sequence":"first","affiliation":[{"name":"Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Pain in Motion, International Research Group, www.paininmotion.be"},{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9, Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-0357","authenticated-orcid":false,"given":"Catherine","family":"Lambert","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"De Smet","sequence":"additional","affiliation":[{"name":"AHVH (Association de l'h\u00e9mophilie\/Hemofilievereniging) Belgian national member organization for haemophilia  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9, Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Secteur de kin\u00e9sith\u00e9rapie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9026","authenticated-orcid":false,"given":"Anthe","family":"Foubert","sequence":"additional","affiliation":[{"name":"Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Pain in Motion, International Research Group, www.paininmotion.be"},{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9, Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2022-5114","authenticated-orcid":false,"given":"Mira","family":"Meeus","sequence":"additional","affiliation":[{"name":"Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Pain in Motion, International Research Group, www.paininmotion.be"},{"name":"Department of Rehabilitation Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"Cedric","family":"Hermans","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-878X","authenticated-orcid":false,"given":"Nathalie Anne","family":"Roussel","sequence":"additional","affiliation":[{"name":"Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00760-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13377"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12858"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.20.00082"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13509"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2021.03.157"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9694-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00393-7"},{"key":"e_1_2_9_11_1","unstructured":"FGOV.Wet inzake experimenten op de menselijke persoon 7 mei 2004.2004;http:\/\/www.ejustice.just.fgov.be\/eli\/wet\/2004\/05\/07\/2004022376\/justel\/"},{"key":"e_1_2_9_12_1","volume-title":"The Brief Pain Inventory User Guide","author":"Charles S","year":"2009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S141389"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00540.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1124"},{"key":"e_1_2_9_17_1","volume-title":"Applied Statistics for the Behavioral Sciences","author":"Hinkle DE","year":"2002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13025"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13214"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13548"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.025"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13614"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13862"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13441"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12060"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13868"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12912"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14469"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh201688784-88"},{"issue":"4","key":"e_1_2_9_31_1","first-page":"309","article-title":"Pain experience in hemophilia patients: a hermeneutic phenomenological study","volume":"4","author":"Rambod MP","year":"2016","journal-title":"Int J Community Based Nurs Midwifery"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.05.023"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2408-18.2018"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S202773"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14321"},{"key":"e_1_2_9_36_1","article-title":"Belgian population norms for the EQ\u20105D\u20105L, 2018","author":"Van Wilder L","year":"2021","journal-title":"Qual Life Res"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00178-H"},{"key":"e_1_2_9_38_1","volume-title":"International Handbook of Survey Methodology","author":"EdithDdeLeeuw JH","year":"2008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14009"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T11:59:44Z","timestamp":1699012784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/hae.14747"],"URL":"https:\/\/doi.org\/10.1111\/hae.14747","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"assertion":[{"value":"2022-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}