{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:39:38Z","timestamp":1770341978104,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","award":["40017"],"award-info":[{"award-number":["40017"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>People with haemophilia (PwH) suffer from knee and ankle joint pain, but the association with structural damage remains underexplored. They report activity limitations but it is unclear which factors contribute to lower limb activity limitations (LL\u2010AL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed (i) to analyse the association between ankle joint pain and structure and (ii) explore the contribution of haemophilia\u2010related, individual and psychological factors to LL\u2010AL in PwH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 104 moderate\/severe PwH. Ankle pain intensity was assessed with a numeric rating scale and pain sensitivity with algometry (pressure pain threshold (PPT<jats:sub>A<\/jats:sub>)). Ankle structure was assessed with MRI (IPSG\u2010MRI) and ultrasound (HEAD\u2010US), joint health with the Haemophilia Joint Health Score (HJHS). The HAL\u2010LOWCOM subscore evaluated LL\u2010AL. A Spearman correlation analysed the correlation between ankle pain and structure. The contribution of haemophilia\u2010related factors (joint health, overall pain (Brief Pain Inventory\u2010Pain Severity (BPI\u2010PS)), functional status (2\u2010Minute\u2010Walking\u2010Distance, Timed Up and Go); individual factors (age, BMI) and psychological factors (fear and avoidance beliefs over physical activity (FABQ\u2010PA) and work (FABQ\u2010Work), anxiety and depression) to LL\u2010AL was explored using a regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only low correlations were found between ankle pain intensity and structure (IPSG\u2010MRI, HEAD\u2010US). PPT<jats:sub>A<\/jats:sub> was unrelated to structure. Altogether, HJHS, overall pain (BPI\u2010PS), FABQ\u2010Work and age explained 69% of HAL\u2010LOWCOM variance, with 65% explained by the combination of HJHS and BPI\u2010PS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No meaningful associations were found between ankle pain and structural damage, suggesting that other factors may contribute to PwH's ankle pain. In contrast, mainly haemophilia\u2010related factors explained LL\u2010AL variance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14749","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:48:04Z","timestamp":1674668884000},"page":"648-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Discordance between joint pain and imagery severity in the ankle joint and contributors of lower limb activity limitations in adults with haemophilia: A cross\u2010sectional study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-7112","authenticated-orcid":false,"given":"Val\u00e9rie\u2010Anne","family":"Chantrain","sequence":"first","affiliation":[{"name":"Research Group (MOVANT), Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Pain in Motion International Research 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