{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:10:23Z","timestamp":1776204623883,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>People with mild haemophilia (PWMH) experience sporadic bleeds and are less likely to receive an early diagnosis, appropriate treatment and medical care. Arthropathy is a key determinant of health\u2010related quality of life (QoL), producing pain, limitations in mobility and daily activities. The aim of this study is to evaluate the incidence, risk factors and QoL associated with arthropathy in PWMH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Observational, cross\u2010sectional cohort study. Data were collected in a single interview and evaluated by a physiotherapist and an orthopaedist and analysed on demographics; baseline factor levels; as well as clinical (Haemophilia Joint Health Score [HJHS]), ultrasound (Haemophilia Early Arthropathy Detection with Ultrasound [HEAD\u2010US]), radiological (Pettersson score [PS]), pain (visual analogue scale [VAS]) and QoL evaluations. We defined arthropathy when at least one of the joints shown with a HEAD\u2010US score\u00a0\u2265\u00a01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010five patients and 510 joints were included. Patients\u2019 mean age was 35.9\u00a0years\u2010old. Median age was 44.2 in patients with arthropathy versus 14.9 in patients without; the difference was statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). In patients over 20\u00a0years old, 90.5% shown arthropathy. Only 24 (28%) patients had no joint damage (HEAD\u2010US\u00a0=\u00a00), and 61 (72%) had at least one joint with a HEAD\u2010US\u00a0\u2265\u00a01. The ankle was the most affected joint. Patient age was found to be the most important risk factor associated with the development of arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Joint damage as a result of prior hemarthrosis was the most relevant factor associated with lower QoL, and emphasised the importance of early diagnosis and appropriate management in this particular population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14750","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:46:51Z","timestamp":1674668811000},"page":"530-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["How mild is mild haemophilia?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-2105","authenticated-orcid":false,"given":"Carla","family":"Daffunchio","sequence":"first","affiliation":[{"name":"Haemophilia Foundation CABA  Argentina"},{"name":"HGA Dr, Juan A. Fern\u00e1ndez CABA  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-2430","authenticated-orcid":false,"given":"Maria E.","family":"Landro","sequence":"additional","affiliation":[{"name":"Haemophilia Foundation CABA  Argentina"},{"name":"HGA Dr, Juan A. Fern\u00e1ndez CABA  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Galatro","sequence":"additional","affiliation":[{"name":"Haemophilia Foundation CABA  Argentina"},{"name":"HGA Dr, Juan A. 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