{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:57:35Z","timestamp":1773388655624,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia is the most common severe congenital bleeding disorder and can significantly influence patients\u2019 quality of life. The health\u2010related quality of life (HRQoL) is a multi\u2010dimensional concept that assess effect of different aspects of health status, including physical, mental, and social domains. Identification of the factors affecting the HRQoL of Persons with Haemophilia (PWH) can guide health care system to better management of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study is to evaluate HRQoL in PWH in Afghanistan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on 100 PWH in Kabul City, Afghanistan. Data were collected using 36\u2010Item\u2010Short\u2010Form Health Survey (SF\u201036) questionnaire and analysed using correlation coefficients and regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean scores for the SF\u201036 questionnaire 8 domains range from 33\u00a0\u00b1\u00a038.3 to 58.15\u00a0\u00b1\u00a020.5. The highest mean value belongs to physical function (PF) (58.15), whereas the lowest is related to restriction of activities due to emotional problems (RE) (33.00). A significant association (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.005) was observed between all domains of SF\u201036 and patients\u2019 age except for PF (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.055) and general health (GH) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.75). A significant association was also observed between all HRQoL domains and the severity of haemophilia (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The severity of haemophilia was the significant predictor for Physical Component Summary (PCS) and Mental Component Summary (MCS) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the reduced HRQoL in Afghan PWH, special attention by health care system should be paid to improve patients\u2019 quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14772","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T18:38:53Z","timestamp":1677868733000},"page":"770-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health\u2010related quality of life in persons with haemophilia in Afghanistan"],"prefix":"10.1111","volume":"29","author":[{"given":"Sayed Mohammad Reza","family":"Hosseini","sequence":"first","affiliation":[{"name":"Medical Research Center Kateb University  Kabul Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-8095","authenticated-orcid":false,"given":"Sayed Hamid","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Medical Research Center Kateb University  Kabul Afghanistan"},{"name":"Afghanistan National Charity Organization for Special Diseases (ANCOSD)  Kabul Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-3741","authenticated-orcid":false,"given":"Seyed Alireza","family":"Mesbah\u2010Namin","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Department of Clinical Biochemistry Tarbiat Modares University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Tabibian","sequence":"additional","affiliation":[{"name":"Hamin Tis Research Institute  Tehran 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