{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:26:43Z","timestamp":1771046803694,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In the past HIV infection was a common complication of haemophilia therapy. Gene therapy trials in Haemophilia patients using rAAV have shown promising results; Unfortunately, the majority of gene therapy trials studies have excluded HIV positive patients. We decided to systematically review the published clinical trials using rAAV for HIV prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was performed to identify studies evaluating clinical trials using rAAV for HIV. The search was conducted using the MEDLINE\/PubMed databases. Search keywords included \u2018gene therapy\u2019, \u2018adeno\u2010associated virus\u2019, \u2018HIV\u2019 and \u2018clinical trial\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three studies met our inclusion criteria. Two were phase 1 studies and one was a phase 2 study. One study examined an AAV coding for human monoclonal IgG1 antibody whereas the other two studies delivered a vector coding for viral protease and part of reverse transcriptase. All studies administered the vaccine intramuscularly and showed a response as well a good safety profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The concept of using a viral vector to prevent a viral infection is revolutionary. Due to the paucity of information regarding application of any gene therapy in HIV patients and the potential use of gene therapy in haemophilia patients with HIV in the future warrants attention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14780","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T16:54:27Z","timestamp":1679590467000},"page":"784-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A systematic review of adeno\u2010associated virus gene therapy clinical trials for HIV \u2013 A potential solution for patients with haemophilia and HIV?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-0336","authenticated-orcid":false,"given":"Sarina","family":"Levy\u2010Mendelovich","sequence":"first","affiliation":[{"name":"National Hemophilia Center, Institute of Thrombosis and Hemostasis Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Amalia Biron Research Institute of Thrombosis and Hemostasis, Sackler School of Medicine Tel Aviv University  Israel"},{"name":"Talpiot leadership program Sheba Medical center  Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Tisch Cancer Institute Icahn School of Medicine at Mount Sinai  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Schapiro","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Institute of Thrombosis and Hemostasis Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Soffer","sequence":"additional","affiliation":[{"name":"Internal Medicine B, Assuta Medical Center, Ashdod Israel and Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Klang","sequence":"additional","affiliation":[{"name":"Talpiot leadership program Sheba Medical center  Tel\u2010Hashomer Israel"},{"name":"Department of Diagnostic Imaging, Chaim Sheba Medical Center, Sackler Faculty of Medicine Tel\u2010Aviv University  Tel Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-2557","authenticated-orcid":false,"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Institute of Thrombosis and Hemostasis Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Amalia Biron Research Institute of Thrombosis and Hemostasis, Sackler School of Medicine Tel Aviv University  Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"HIV Surveillance Annual Report 2020 (Published July 2021) Division of HIV and STD Programs Department of Public Health County of Los Angeles. Published annually by the California Department of Public Health Center for Infectious Diseases Office of AIDS Sacramento California.2020AnnualHIVSurveillanceReportUpdated9\u20102021_fig1fig2update.pdf(lacounty.gov)"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2015.06.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2020010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706910"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.08.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708483"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108046"},{"key":"e_1_2_11_9_1","first-page":"317","article-title":"Adeno\u2010associated virus (AAV) as a vector for gene therapy","volume":"31","author":"Naso MF","year":"2017","journal-title":"Bio Drugs"},{"key":"e_1_2_11_10_1","unstructured":"https:\/\/www.europeanpharmaceuticalreview.com\/news\/174534\/first\u2010patient\u2010dosed\u2010with\u2010hiv\u2010gene\u2010therapy\/)"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2480"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30003-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0292"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0242"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02213.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.232132"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2009.2777"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030338.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17438"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15486-X"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-10-0593"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835f1db0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051263"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2113708"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.658399"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0911-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300548"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.10.053"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T14:08:15Z","timestamp":1716905295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/hae.14780"],"URL":"https:\/\/doi.org\/10.1111\/hae.14780","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]},"assertion":[{"value":"2022-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}