{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T13:07:34Z","timestamp":1769864854321,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acquired haemophilia A (AHA) is a rare disease. The risk factors have yet to be studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to identify risk factors for late\u2010onset AHA in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based cohort study was conducted using data from the Shizuoka Kokuho Database. The study population was defined as individuals aged \u226560 years. Cause\u2010specific Cox regression analysis was performed to calculate hazard ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,160,934 registrants, there were 34 patients with newly diagnosed AHA. The mean follow\u2010up period was 5.6 years, and the incidence of AHA was 5.21 per million person\u2010years. Myocardial infarction, diabetes mellitus, solid tumors, antimicrobial agents, phenytoin and anti\u2010dementia drugs, which showed significant differences in the univariate analysis, were excluded from the multivariable analysis because of the small number of cases. Multivariable regression analysis showed that the presence of Alzheimer's disease (hazard ratio [HR]:4.28, 95% confidence interval [CI]:1.67\u201010.97) and rheumatic disease (HR:4.65, 95% CI:1.79\u201012.12) increased the risk of AHA development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that comorbid Alzheimer's disease is a risk factor of AHA incidence in the general population. Our findings provide insight into the etiology of AHA, and the proof of the coexistence of Alzheimer's disease may support the recent notion that Alzheimer disease is an autoimmune disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14793","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T08:23:02Z","timestamp":1682410982000},"page":"799-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors, treatment and survival rates of late\u2010onset acquired haemophilia A: A cohort study from the Shizuoka Kokuho Database"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-2023","authenticated-orcid":false,"given":"Aya","family":"Shoji\u2010Asahina","sequence":"first","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health, Aoi\u2010ku  Shizuoka Japan"},{"name":"Department of Clinical 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