{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:52:11Z","timestamp":1791244331553,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The diagnosis of von Willebrand disease (VWD) is complex and challenging, especially when diagnostic resources are limited. This results in a lack of consistency in identifying and reporting the number of people with VWD and variations in the VWD prevalence worldwide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyze the reported prevalence of VWD worldwide in relation to income classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on the VWD prevalence from the World Federation of Hemophilia Annual Global Survey, national registries of Australia, Canada, and the United Kingdom, and the literature were analysed. The income level of each country was classified according to the World Bank.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean VWD prevalence worldwide was 25.6 per million people. The VWD prevalence for high\u2010income countries (HIC) of 60.3 per million people was significantly greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) than upper middle (12.6), lower middle (2.5) and low (1.1) income countries. The type 3 VWD prevalence for HIC of 3.3 per million people was significantly greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) than lower middle (1.3) and low income (0.7) countries. The reported VWD prevalence was greater among females than males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reported VWD prevalence varied considerably across and within income classifications. The variability of type 3 VWD prevalence was less than the VWD prevalence (all types). The variability in detection and diagnosis of type 1 VWD presents a challenge in forming a consistent prevalence value across countries and income classifications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14810","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:57:54Z","timestamp":1686182274000},"page":"975-986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Reported prevalence of von Willebrand disease worldwide in relation to income classification"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-329X","authenticated-orcid":false,"given":"Jeffrey S.","family":"Stonebraker","sequence":"first","affiliation":[{"name":"Department of Business Management Poole College of Management North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Mike Gent Chair in Health Care Research, Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4216","authenticated-orcid":false,"given":"Michelle","family":"Lavin","sequence":"additional","affiliation":[{"name":"Irish Centre for Vascular Biology School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland  Dublin Ireland"},{"name":"National Coagulation Centre St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-7093","authenticated-orcid":false,"given":"Suely M.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-5020","authenticated-orcid":false,"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Hematology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn F.","family":"Pierce","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia, Montr\u00e9al  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-4474","authenticated-orcid":false,"given":"Donna","family":"Coffin","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia, Montr\u00e9al  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellia","family":"Tootoonchian","sequence":"additional","affiliation":[{"name":"World Federation of Hemophilia, Montr\u00e9al  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-7939","authenticated-orcid":false,"given":"Michael","family":"Makris","sequence":"additional","affiliation":[{"name":"Sheffield Haemophilia and Thrombosis Centre  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003265"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14465"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281028"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613992"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444329926.ch7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"377","article-title":"Prevalence of von Willebrand's disease among US adults","volume":"70","author":"Miller CH","year":"1987","journal-title":"Blood"},{"issue":"6","key":"e_1_2_11_9_1","first-page":"893","article-title":"Prevalence of von Willebrand disease in children: a multiethnic study","volume":"123","author":"Werner EJ","year":"1993","journal-title":"Indian J Pediatr"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1208"},{"key":"e_1_2_11_11_1","unstructured":"World Federation of Hemophilia.2022. 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