{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:20:44Z","timestamp":1767612044294,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Inhibition of tissue factor pathway inhibitor (TFPI) is a potential new mode of action to achieve haemostasis in haemophilia A and B patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Knowledge about potential developmental changes of TFPI levels during childhood are a prerequisite to translate adult doses of TFPI inhibitors to doses in paediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study we present longitudinal data for total TFPI concentrations (TFPI\u2010T) and TFPI activity (TFPI\u2010A) from 48 paediatric Haemophilia A patients in the age range from 3 to 18 years (2\u201312 observations per patient).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TFPI\u2010T and TFPI\u2010A tend to decrease over age during childhood. Lowest values were observed between 12 and\u00a0&lt;18 years. On average, TFPI\u2010T and TFPI\u2010A were lower in adolescent haemophilia patients than in adult haemophilia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, the presented information on TFPI levels in children adds to the current knowledge of developmental haemostasis and it can be helpful in evaluating how children respond to haemophilia treatment including the new class of anti\u2010TFPI compounds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14813","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T15:28:53Z","timestamp":1687188533000},"page":"1142-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal observations of TFPI levels in paediatric Haemophilia A patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-6197","authenticated-orcid":false,"given":"Stephan","family":"Schwers","sequence":"first","affiliation":[{"name":"Bayer AG Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-3115","authenticated-orcid":false,"given":"Anita","family":"Shah","sequence":"additional","affiliation":[{"name":"Bayer Whippany New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-6850","authenticated-orcid":false,"given":"Camila","family":"Linardi","sequence":"additional","affiliation":[{"name":"Bayer Whippany New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bayer AG Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Willmann","sequence":"additional","affiliation":[{"name":"Bayer AG Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201011\u2010512764"},{"key":"e_1_2_9_3_1","first-page":"1087","article-title":"Selective cellular expression of tissue factor in human tissues. 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