{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:14:10Z","timestamp":1789661650486,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia B is a debilitating hereditary coagulation disorder characterized by prolonged or spontaneous episodes of bleeding caused by a deficiency of endogenous factor IX. In Algeria, even though many studies are being carried out to evaluate the prevalence and management of haemophilia B, there is a paucity of locally published literature that can be used to understand the most recent information on the disease's epidemiology, diagnostic techniques and treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this manuscript is to raise awareness among patients and family clinicians about current practices, recent developments and unmet needs related to haemophilia B in Algeria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search was conducted through online scientific databases to review publications regarding haemophilia B in Algeria. Exclusions of the review include case studies, interregional comparisons, abstract\u2010only papers and studies outside the range of 2012\u20132022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The findings discussed relate to the epidemiology of haemophilia B in Algeria, the clinical diagnostic process, disease symptoms, the benefits of molecular and genetic testing, advancements in prophylactic care, as well as unmet needs hindering the progression of optimal haemophilia B management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings are crucial to encourage the maintenance of national registries with updated epidemiological data, facilitate early and timely detection of disease symptoms, improve the provision of diagnostic facilities and enhance the overall treatment landscape for better patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14827","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T16:57:57Z","timestamp":1689785877000},"page":"1176-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Haemophilia B in Algeria: Realities and therapeutic perspectives"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3214-9363","authenticated-orcid":false,"given":"Mohamed Salim","family":"Nekkal","sequence":"first","affiliation":[{"name":"Issad Hassani Hospital Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Mesli","sequence":"additional","affiliation":[{"name":"Dr Tidjani Damerdji University Hospital Tlemcen Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Grifi","sequence":"additional","affiliation":[{"name":"Annaba University Hospital Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacira","family":"Cherif","sequence":"additional","affiliation":[{"name":"Issad Hassani Hospital Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohra","family":"Ouchenane","sequence":"additional","affiliation":[{"name":"Constantine Dr Benbadis University Hospital Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Said","family":"Bettayeb","sequence":"additional","affiliation":[{"name":"Hospital Business and Rare Diseases Pfizer Inc. Ltd Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052762"},{"issue":"6","key":"e_1_2_9_3_1","first-page":"535","article-title":"Diagnosis and care of patients with mild haemophilia: practical recommendations for clinical management","volume":"16","author":"Benson G","year":"2018","journal-title":"Blood Transfus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1208"},{"key":"e_1_2_9_6_1","unstructured":"World Federation of Hemophilia.Annual Global Survey 2020.2020."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2018.1489719"},{"key":"e_1_2_9_8_1","unstructured":"Association Nationale Des Hemophiles Algeriens.2016. 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