{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:03:21Z","timestamp":1773047001400,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Joint pain is the hallmark of haemophilia; therefore it seems clinically rather a musculoskeletal than a bleeding disorder. Although joint pain in people with haemophilia (PwH) is a complex and multidimensional problem, pain assessment remains primarily focused on the structural evaluation of their joints. Whereas, only few data are available on the potential implication of psychophysical and psychological factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to perform a psychophysical pain assessment including quantitative sensory testing (QST) and an evaluation of psychological factors in a large sample of PwH, to get insight into the individuals\u2019 pain system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010nine adults (36.9\u00a0\u00b1\u00a013.5 years) with moderate\/severe haemophilia A\/B and 46 healthy controls filled in self\u2010reported pain and psychological questionnaires and underwent a QST evaluation including static and dynamic tests. Static tests focused on the determination of thermal detection and pain thresholds and mechanical pressure pain thresholds. Dynamic tests evaluated pain facilitation and the efficacy of endogenous pain inhibition. Besides comparing PwH and healthy controls, between\u2010subgroup differences were studied in PwH based on their pain distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study revealed increased thermal and mechanical pain sensitivity and the presence of unhelpful psychological factors such as anxiety\/depression in PwH. Among the subgroups, especially PwH with widespread pain showed altered somatosensory functioning. Enhanced pain facilitation and impaired efficacy of endogenous pain inhibition in PwH could not be observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altered somatosensory functioning and unhelpful psychological factors, appear to play an important role in the pathophysiology of pain in PwH, especially in PwH with widespread pain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14830","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T05:04:04Z","timestamp":1690952644000},"page":"1243-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Psychophysical assessment of pain in adults with moderate and severe haemophilia: A cross\u2010sectional study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9026","authenticated-orcid":false,"given":"Anthe","family":"Foubert","sequence":"first","affiliation":[{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Facult\u00e9 des Sciences de la Motricit\u00e9 Universit\u00e9 catholique de Louvain Louvain\u2010La\u2010Neuve Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie\u2010Anne","family":"Chantrain","sequence":"additional","affiliation":[{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Facult\u00e9 des Sciences de la Motricit\u00e9 Universit\u00e9 catholique de Louvain Louvain\u2010La\u2010Neuve Belgium"},{"name":"Neuromusculoskeletal Lab (NMSK), Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Meeus","sequence":"additional","affiliation":[{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Department of Rehabilitation Sciences Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Maes","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Hospital Antwerp Edegem Belgium"},{"name":"Laboratory of Experimental Medicine and Pediatrics University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Haenen","sequence":"additional","affiliation":[{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Department of Rehabilitation Sciences KU Leuven University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"additional","affiliation":[{"name":"Neuromusculoskeletal Lab (NMSK), Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain Louvain\u2010la\u2010Neuve Belgium"},{"name":"Haemostasis and Thrombosis Unit, Division of Hematology Clinique universitaires Saint\u2010Luc Brussels Belgium"},{"name":"Secteur de kin\u00e9sith\u00e9rapie Cliniques universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-0357","authenticated-orcid":false,"given":"Catherine","family":"Lambert","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit, Division of Hematology Clinique universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"C\u00e9dric","family":"Hermans","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit, Division of Hematology Clinique universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-878X","authenticated-orcid":false,"given":"Nathalie","family":"Roussel","sequence":"additional","affiliation":[{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6110107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-03-0021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00540.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13509"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12175"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14544"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00680.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13472"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4173"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20130331"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34646"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13939"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.08.010"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.01.010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000418"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00117.x"},{"key":"e_1_2_10_22_1","first-page":"397","volume-title":"Quantitative Sensory Testing Handbook of Clinical Neurology","author":"Yarnitski D","year":"2006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2017.07.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.937"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1661-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqw041"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187961"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1619823"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2011.00493.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.11.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00219-1"},{"issue":"5","key":"e_1_2_10_33_1","first-page":"309","article-title":"A validation of the hospital anxiety and depression scale","volume":"38","author":"Hatta H","year":"1998","journal-title":"\u5fc3\u8eab\u533b\u5b66"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.02.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab343"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2011.10.003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2003.09.004"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.605"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.09.010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2021.102489"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000126"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.09.001"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12672"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa276"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12600"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001326"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13370"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2014.499.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12289"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.04.030"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.08.001"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.003"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(02)00344-5"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153203"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20150492"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000689"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001427"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-3990-2"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.05.009"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.10.007"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215519900533"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31826f9a71"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T04:50:03Z","timestamp":1709182203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/hae.14830"],"URL":"https:\/\/doi.org\/10.1111\/hae.14830","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}