{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:24Z","timestamp":1787014284103,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Haemophilia is characterized by recurrent joint bleeding caused by a lack of clotting factor VIII or IX. Due to repeated joint bleeding, end\u2010stage arthropathy occurs in relatively young patients. A total knee replacement (TKR) can be a solution. However, TKR may be complicated by perioperative and postoperative bleeds despite clotting factor therapy. The aim of this study was to evaluate the prevalence of pre\u2010operative synovial hyperaemia and the effects of Genicular Artery Embolization on synovial hyperaemia and 3\u2010month postoperative joint bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, all patients with haemophilia who underwent periarticular catheter angiography between 2009 and 2020 were evaluated after written informed consent. Synovial hyperaemia on angiography was scored by an interventional radiologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010three angiography procedures in 24 patients were evaluated. Median age was 54.4 years (IQR 48.4\u201365.9). Preoperative synovial hyperaemia was observed in 21\/33 joints (64%). Moderate and severe synovial hyperaemia was observed in 10\/33 joints (30%). Synovial hyperaemia decreased in 13\/15 (87%) joints after embolization. Three\u2010month postoperative joint bleeding occurred in 5\/32 joints: in 2\/18 joints (11%) without synovial hyperaemia and in 3\/14 joints (21%) with mild synovial hypertrophy. Non\u2010embolized and embolized joints did not differ regarding 3\u2010month postoperative bleeding (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.425). No complications were observed after embolization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One\u2010third of patients with haemophilia requiring a TKR had moderate or severe synovial hyperaemia which can be reduced safely by Genicular Artery Embolization prior to TKR. Three\u2010month postoperative bleeding appears to occur independently of the presence of residual mild synovial hyperaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14835","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T04:56:09Z","timestamp":1691384169000},"page":"1351-1358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pre\u2010operative synovial hyperaemia in haemophilia patients undergoing total knee replacement and the effects of genicular artery embolization: A retrospective cohort study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-8555","authenticated-orcid":false,"given":"Wouter","family":"Foppen","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene C.","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-4385","authenticated-orcid":false,"given":"Flora H. P.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Verlind","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-5524","authenticated-orcid":false,"given":"Lize F. D.","family":"van Vulpen","sequence":"additional","affiliation":[{"name":"Center for Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Charles","family":"Vogely","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten W.","family":"Barentsz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Division of Imaging &amp; Oncology University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01268.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200202000-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B8.23922"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13236"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-470898"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"132","article-title":"Discontinuing early prophylaxis in young adults with severe haemophilia A: deterioration of joint status after 10 years despite low bleeding 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