{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:56:35Z","timestamp":1781121395887,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The impact of moderate haemophilia on health\u2010related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII\/factor IX activity (FVIII\/FIX:C) below 3\u00a0IU\/dL were associated with a more severe bleeding phenotype than predicted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, multicentre study covering patients with MHA and MHB in Sweden, Finland, and Norway. HRQoL was assessed with the EuroQoL 5\u2010Dimensions (EQ\u20105D) form and PA with the International Physical Activity Questionnaire among participants aged \u226515 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report on 104 patients aged 15\u201384 years from the MoHem study. Overall, EQ\u20105D utility was .85 (median) (Q1\u2013Q3 0.73\u20131.0) with corresponding visual analogue scale (VAS) 80 (70\u201390), which were similar regardless of treatment modality, FVIII\/FIX:C, and MHA or MHB. Pain and mobility were most frequently affected dimensions. Utility (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2010.54), VAS (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2010.42), and PA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2010.32) correlated negatively with arthropathy (HJHS). Only patients aged 41\u201350 years displayed lower utility (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and VAS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) than the Norwegian population norm. Patients on prophylaxis aged 35\u201354 years reported higher PA than those treated on\u2010demand (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haemophilic arthropathy had negative impact on HRQoL and PA in Nordic patients with moderate haemophilia. Middle\u2010aged patients captured lower utility and VAS than observed in the general population. Tailored prophylaxis and improved joint health may influence positively on HRQoL and PA also in moderate haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14899","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:48:33Z","timestamp":1700603313000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Health\u2010related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study)"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-7089","authenticated-orcid":false,"given":"Ragnhild J.","family":"M\u00e5seide","sequence":"first","affiliation":[{"name":"Department of Haematology Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bruzelius","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"},{"name":"Department of Haematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Frisk","sequence":"additional","affiliation":[{"name":"Pediatric Coagulation Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-7288","authenticated-orcid":false,"given":"Vuokko","family":"Nummi","sequence":"additional","affiliation":[{"name":"Coagulation Disorders Unit Haematology Comprehensive Cancer Centre Helsinki University Hospital and Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki 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