{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:01:38Z","timestamp":1787839298820,"version":"build-2784847793"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Joint damage due to haemarthrosis can be effectively monitored with point\u2010of care ultrasound using the Haemophilia Early Arthropathy Detection with US (HEAD\u2010US) scoring system. A post hoc comparative analysis of the joint status of patients with severe haemophilia A (HA) or B (HB) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The databases of two observational, cross\u2010sectional studies that recruited patients with HA or HB from 12 Spanish centres were analysed to compare the status of the elbows, knees and ankles in patients with severe disease according to treatment modality. The HEAD\u2010US score was calculated in both studies by the same trained operators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 95 HA and 41 HB severe patients were included, with a mean age of 35.2\u00a0\u00b1\u00a011.8 and 32.7\u00a0\u00b1\u00a014.2 years, respectively. The percentage of patients who received prophylaxis, over on\u2010demand (OD) treatment, was much higher in HA (91.6%) than in HB (65.8%) patients. With a similar number of target joints, the HEAD\u2010US score was zero in 6.3% HA and 22.0% HB patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), respectively. The HA population showed significantly worse HEAD\u2010US scores. Whilst osteochondral damage occurred more frequently in patients OD or tertiary prophylaxis, our data suggest that articular damage is less prominent in primary\/secondary prophylaxis, regardless of the type of haemophilia. These latter treatment modalities were also associated with a lower prevalence of synovial hypertrophy, particularly in HB patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This post hoc analysis indicates that joint status seems to be significantly influenced by haemophilia type (HA or HB) and treatment modality in these severe Spanish populations with severe disease. Continuing HEAD\u2010US monitoring for the early detection and management of intra\u2010articular abnormalities, as well as more efficiently tailored therapies should be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14924","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:38:57Z","timestamp":1706503137000},"page":"513-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A post hoc comparative real\u2010world analysis of HEAD\u2010US score for joint health assessment of patients with severe haemophilia A and B in Spain"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-4288","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"\u00c1lvarez\u2010Rom\u00e1n","sequence":"first","affiliation":[{"name":"Hospital Universitario La Paz  Madrid 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