{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:46Z","timestamp":1747185106599,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Flexion deformity of the knee is a common complication following recurrent haemarthrosis in persons with haemophilia (PWH) on episodic factor replacement therapy, restricting independent mobility. There is limited literature on the comprehensive management of this condition. This report provides the outcome of a staged multidisciplinary approach for the correction of knee flexion deformity (KFD) even in limited resource settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>The data of 49 consecutive PWH who were treated for KFD were analysed. The approach included graded physical therapy (PT), followed by serial casting and\/or mobilisation under anaesthesia (MUA). MUA was done in carefully selected knees. Surgical correction was opted when non\u2010surgical methods failed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 49 patients (55 knees), with a median KFD of 40 degrees (range: 10\u201390), 26\/55 (47%) were corrected by graded PT. With serial casting, 9\/19 (47%) knees had their KFD corrected. MUA was done for 11 knees of which five achieved correction (45%). Surgical correction was required for only seven knees (12.7%). Following this approach, KFD improved from 40 degrees (range: 10\u201390) to 15 degrees (range: 0\u201340), with only minor loss of flexion from 105 (range: 60\u2013155) to 90\u00a0degrees (range: 30\u2013150). Out of 55 KFD, 46 (83.6%) KFD were corrected; non\u2010surgical, 39 (70.9%) and surgery, seven (12.7%). The remaining patients (nine KFD; 16.4%) were able to achieve their functional goal despite not meeting the correction criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that in PWH, functionally significant KFD correction can be achieved in about 71%, through non\u2010surgical methods, even without prophylactic factor replacement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14940","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T06:30:22Z","timestamp":1705905022000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010surgical correction of knee flexion deformity in persons with haemophilia: A staged multidisciplinary approach"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-5838","authenticated-orcid":false,"given":"Merlyn","family":"Tilak","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy Ann","family":"John","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anumeha","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriya","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-1249","authenticated-orcid":false,"given":"Prince","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Cherian","sequence":"additional","affiliation":[{"name":"Department 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M.","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nambiathayil Abubacker","family":"Fouzia","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aby","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-5020","authenticated-orcid":false,"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu 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