{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:54:40Z","timestamp":1762876480119,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009248","name":"Innovatiefonds Zorgverzekeraars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Non\u2010severe haemophilia A patient can be treated with desmopressin or factor VIII (FVIII) concentrate. Combining both may reduce factor consumption, but its feasibility and safety has never been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed the feasibility and safety of combination treatment in nonsevere haemophilia A patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010severe, desmopressin responsive, haemophilia A patients were included in one of two studies investigating peri\u2010operative combination treatment. In the single\u2010arm DAVID study intravenous desmopressin (0.3\u00a0\u03bcg\/kg) once\u2010a\u2010day was, after sampling, immediately followed by PK\u2010guided FVIII concentrate, for maximally three consecutive days. The Little DAVID study was a randomized trial in patients undergoing a minor medical procedure, whom received either PK\u2010guided combination treatment (intervention arm) or PK\u2010guided FVIII concentrate only (standard arm) up to 2 days. Dose predictions were considered accurate if the absolute difference between predicted and measured FVIII:C was \u22640.2 IU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 32 patients (33 procedures) were included. In the DAVID study (<jats:italic>n<\/jats:italic>\u00a0=\u00a021), of the FVIII:C trough levels 73.7% (14\/19) were predicted accurately on day 1 (D1), 76.5% (13\/17) on D2. On D0, 61.9% (13\/21) of peak FVIII:C levels predictions were accurate. In the Little DAVID study (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), on D0 83.3% (5\/6) FVIII:C peak levels for both study arms were predicted accurately. Combination treatment reduced preoperative FVIII concentrate use by 47% versus FVIII monotherapy. Desmopressin side effects were mild and transient. Two bleeds occurred, both despite FVIII:C\u00a0&gt;\u00a01.00 IU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peri\u2010operative combination treatment with desmopressin and PK\u2010guided FVIII concentrate dosing in nonsevere haemophilia A is feasible, safe and reduces FVIII consumption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14946","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:13:46Z","timestamp":1707718426000},"page":"355-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peri\u2010operative desmopressin combined with pharmacokinetic\u2010guided factor VIII concentrate in non\u2010severe haemophilia A patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-658X","authenticated-orcid":false,"given":"Lorenzo G. R.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Hematology Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-4682","authenticated-orcid":false,"given":"Lisette M.","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinier M.","family":"van Hest","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy and Clinical Pharmacology Amsterdam University Medical Centers\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-0465","authenticated-orcid":false,"given":"Karina","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta A. P.","family":"Laros\u2010van Gorkom","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Nieuwenhuizen","sequence":"additional","affiliation":[{"name":"Department of Hematology M\u00e1xima Medical Center  Veldhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Eikenboom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Thrombosis and Hemostasis Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3281-926X","authenticated-orcid":false,"given":"Floor C. J. I.","family":"Heubel\u2010Moenen","sequence":"additional","affiliation":[{"name":"Department of Hematology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanda","family":"Uitslager","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Coppens","sequence":"additional","affiliation":[{"name":"Department of Hematology Amsterdam University Medical Centers\u2010University of Amsterdam  Amsterdam The Netherlands"},{"name":"Pulmonary Hypertension &amp; Thrombosis Amsterdam Cardiovascular Sciences  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-4360","authenticated-orcid":false,"given":"Karin","family":"Fijnvandraat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Amsterdam University Medical Centers\u2010University of Amsterdam Emma Children's Hospital  Amsterdam The Netherlands"},{"name":"Department of Plasma Proteins Sanquin Research  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebtte H. E.","family":"Driessens","sequence":"additional","affiliation":[{"name":"Netherlands Hemophilia Patient Society (NVHP)  Nijkerk The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Polinder","sequence":"additional","affiliation":[{"name":"Department of Public Health Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjon H.","family":"Cnossen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus MC Sophia Children's Hospital Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-1371","authenticated-orcid":false,"given":"Frank W. G.","family":"Leebeek","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron A. A.","family":"Math\u00f4t","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy and Clinical Pharmacology Amsterdam University Medical Centers\u2010University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-4871","authenticated-orcid":false,"given":"Marieke J. H. 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