{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:05:13Z","timestamp":1773047113008,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to assess the reliability and construct validity of ACTIVLIM\u2010Hemo, a newly developed Rasch\u2010built questionnaire designed to evaluate activity limitations in people with haemophilia (PwH), in comparison with the Haemophilia Activities List (HAL), which was developed using Classical Test Theory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 130 participants with haemophilia A or B were included. They underwent various assessments, including joint health scoring (HJHS), functional tests (TUG and 2MWT) and completed questionnaires such as the BPI, IPAQ, HAL and ACTIVLIM\u2010Hemo. Reliability indices and the minimum detectable change (MDC95) were determined for ACTIVLIM\u2010Hemo and for HAL. Construct validity was evaluated through correlations and multiple linear regression, considering demographic and clinical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both ACTIVLIM\u2010Hemo (Person Separation Index\u00a0=\u00a00.92) and HAL (Cronbach's \u03b1\u00a0=\u00a00.98) demonstrated high reliability. The MDC95 for ACTIVLIM\u2010Hemo represented 11.6% of its measurement range, while for HAL, it amounted to 18\/100 score points. Activity limitations measured by both instruments were significantly correlated with demographic and clinical factors. Joint health (HJHS), pain severity (BPI) and walking performance (2MWT) emerged as the main predictors of activity limitations, explaining 75% of the variance in ACTIVLIM\u2010Hemo and 60% in HAL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ACTIVLIM\u2010Hemo stands as a reliable and valid instrument for assessing activity limitations in PwH. Both instruments exhibited significant correlations with demographic and clinical factors, but ACTIVLIM\u2010Hemo displayed a more homogeneous construct. Given its linear scale and lower MDC95 and better targeting, ACTIVLIM\u2010Hemo shows promise as a patient\u2010centric instrument for assessing responsiveness to treatment during individual follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14954","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:29:00Z","timestamp":1708493340000},"page":"497-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reliability and construct validity of the ACTIVLIM\u2010Hemo and Haemophilia Activities List (HAL) questionnaires in individuals with haemophilia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"first","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Service d'ergoth\u00e9rapie et de kin\u00e9sith\u00e9rapie Cliniques universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain (UCLouvain)  Brussels Belgium"},{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"Cedric","family":"Hermans","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-7112","authenticated-orcid":false,"given":"Val\u00e9rie\u2010Anne","family":"Chantrain","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Pain in Motion International ResearchGroup www.paininmotion.be  Antwerp Belgium"},{"name":"Facult\u00e9 des sciences de la motricit\u00e9 Universit\u00e9 catholique de Louvain (UCLouvain)  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9026","authenticated-orcid":false,"given":"Anthe","family":"Foubert","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp  Wilrijk Belgium"},{"name":"Pain in Motion International ResearchGroup www.paininmotion.be  Antwerp Belgium"},{"name":"Facult\u00e9 des sciences de la motricit\u00e9 Universit\u00e9 catholique de Louvain (UCLouvain)  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-0357","authenticated-orcid":false,"given":"Catherine","family":"Lambert","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit Division of Hematology Cliniques universitaires Saint\u2010Luc Universit\u00e9 catholique de Louvain (UCLouvain)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-8638","authenticated-orcid":false,"given":"Massimo","family":"Penta","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 catholique de Louvain (UCLouvain) Louvain\u2010la\u2010Neuve Belgium"},{"name":"Arsalis SRL  Glabais Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"237","volume-title":"The International Classification of functioning, disability and health","author":"WHO","year":"2001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14642"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14564"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"308","article-title":"Ordinal scales and foundations of misinference","volume":"70","author":"Merbitz C","year":"1989","journal-title":"Arch Phys Med Rehabil"},{"issue":"12","key":"e_1_2_11_6_1","first-page":"857","article-title":"Observations are always ordinal; 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