{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:37:13Z","timestamp":1768423033867,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["IIR\u2010DEU\u2010002286"],"award-info":[{"award-number":["IIR\u2010DEU\u2010002286"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Regular physical activity (PA) is recommended for patients with haemophilia (PwH). For PwH it is crucial to ensure a sufficient factor level to prevent PA\u2010induced bleedings. However, there is a gap in the literature dealing with specific factor levels, which are needed when performing specific types of PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide data on factor VIII (FVIII) levels at the start of PA performed by PwH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective 12\u2010month real\u2010world observational study, 23 PwH recorded every PA they performed and the FVIII levels at the start of the PA using a pharmacokinetic application. PA types were clustered according to the collision and injury risk into three categories (Cat I\u00a0=\u00a0low, Cat II\u00a0=\u00a0medium, Cat III\u00a0=\u00a0high risk). Haemophilia Joint Health Scores (HJHS) were performed at baseline, after 6 and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>795 PA sessions of Cat I, 193 of Cat II, and 23 of Cat III were documented. FVIII levels at the start of PA were different between categories (Cat I: 29.8\u00a0\u00b1\u00a032.1%, Cat II: 38.3\u00a0\u00b1\u00a033.4%, Cat III: 86.6\u00a0\u00b1\u00a029.2%). Out of all PA sessions, 145 (14%) were performed at a factor level of \u22643%. Three PA\u2010induced bleeding occurred. Baseline HJHS was 14.5\u00a0\u00b1\u00a013.6 points and did not change throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides real\u2010life data on FVIII levels at the start of 1011 PA sessions. PwH are mainly active in low\u2010risk sports with higher FVIII levels observed in Cat II and III, respectively. Only three PA\u2010induced bleeding occurred, even though several PA were started with low FVIII levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14965","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T15:35:29Z","timestamp":1708616129000},"page":"419-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Physical activity and factor VIII levels in patients with haemophilia: A real\u2010world prospective observational study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-4891","authenticated-orcid":false,"given":"Fabian","family":"Tomschi","sequence":"first","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal 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Wuppertal Germany"},{"name":"Institute for Experimental Haematology and Transfusion Medicine University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5577-7306","authenticated-orcid":false,"given":"Alexander","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Herzig","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Institute for Experimental Haematology and Transfusion Medicine University of Bonn  Bonn 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