{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:42:52Z","timestamp":1782949372401,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Poor response to platelet and recombinant factor VII administration is a major problem in patients with Glanzmann Thrombasthenia (GT). The risk factors associated with poor response to treatment in these patients are unknown. Some genetic variations of cytokines may contribute to therapy resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated, for the first time, whether genetic polymorphisms on cytokine genes are related to poor treatment response in GT patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 30 patients with GT (15 resistant and 15 non\u2010resistant) and 100 healthy controls. Gene polymorphisms of IL\u201010 and TNF\u2010\u03b1 were analysed using TaqMan Realtime PCR, and IL\u20101, IL\u20101R1 and IL\u20101RN were investigated with the RFLP method. In\u2010silico analyses were performed to predict the potential impact of these polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the resistant group, all patients had a variant of the IL\u201010 gene at the \u20101082 position (rs1800896), with a GG genotype that was significantly more frequent than the non\u2010resistant group. Analysis between healthy controls and GT patients revealed a probable correlation between rs3783550, rs3783553, rs3917356 and rs2234463 and GT. The In\u2010silico study indicated that TNF\u2010\u03b1 rs1800629 and IL\u201010 rs1800896 polymorphisms result in different allelic expressions which may contribute to poor response to therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that polymorphisms in the IL\u201010 and IL\u20101 receptor antagonist genes may play a role in poor therapy response in GT patients. In addition, some polymorphisms in IL\u20101\u03b1, IL1\u2010\u03b2, IL\u20101R1 and IL\u2010R antagonists might be involved in the GT progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14971","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T04:45:02Z","timestamp":1709613902000},"page":"752-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune gene polymorphisms associated with poor response to platelet transfusion and recombinant factor VII administration in Glanzmann thrombasthenia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-1690","authenticated-orcid":false,"given":"Majid","family":"Naderi","sequence":"first","affiliation":[{"name":"Genetics of Non\u2010communicable Disease Research Center Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Children and Adolescents Health Research Center Zahedan University 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