{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:54:55Z","timestamp":1788454495041,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia A negatively affects a patient's quality of life. There is a limited amount of health utility data (a measure of health\u2010related quality of life) available for patients with haemophilia A. This information is crucial for cost\u2010effectiveness analysis for haemophilia A treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of this project is to elicit the health utilities and factors impacting utility values for haemophilia A patients in Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a population\u2010based, cross\u2010sectional, retrospective study of health utilities in patients with haemophilia A using Patient Report Outcomes Burdens and Experiences (PROBE) components from the Canadian Bleeding Disorders Registry (CBDR). A review of the mean utilities for three severity states, defined by clotting factor VIII level, was completed. A multiple linear regression analysis was completed to examine the determinants of health utilities including age, treatment type, chronic pain status, number of limited joints, and bleed rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average utility values (and standard deviations) for patients with haemophilia A in Canada are\u00a0.79(.17),\u00a0.76(.20), and\u00a0.77(.19) for patients with severe, moderate, and mild haemophilia. The regression showed chronic pain status and the number of additional comorbidities as major significant factors (<jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a0.001) in haemophilia A utility. Haemophilia severity was shown to be a major factor with smaller p\u2010value (<jats:italic>p<\/jats:italic>\u2010value\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haemophilia A patients have lower utility than the general population. Chronic pain was shown to be a significant, major factor in health\u2010related quality of life. Our study is essential for valuing health outcomes in haemophilia A\u2010related cost\u2010effectiveness analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14979","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T15:53:36Z","timestamp":1710950016000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Health utilities in adults with hemophilia A: A retrospective cohort study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9719-6508","authenticated-orcid":false,"given":"Sam","family":"Hirniak","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Science University of Waterloo  Kitchener ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-1653","authenticated-orcid":false,"given":"Andrea N","family":"Edginton","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Science University of Waterloo  Kitchener ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhd. 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