{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:44:09Z","timestamp":1784889849685,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune tolerance induction (ITI) is the only treatment to eradicate inhibitors in people with severe haemophilia A with inhibitors. Since the risk of inhibitor development is greater among Black and Hispanic persons, it has been hypothesized that race and ethnicity may influence ITI success. Limited studies have evaluated this hypothesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the success of ITI according to race and ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants who entered the Community Counts (CC) Registry between 2013 and 2017, were aged \u22653 years at study entry, and received ITI were included (<jats:italic>n<\/jats:italic>\u00a0=\u00a0559). The proportion of participants with successful ITI was examined with adjusted prevalence ratios (aPRs) and corresponding 95% confidence intervals (95% CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 559 participants, 56.9%, 19.1%, 18.1% and 4.3% were Non\u2010Hispanic (NH) White, NH Black, Hispanic and Asian, respectively, and 1.7% were coded as other or missing.\u00a0Approximately 80% of Hispanic, NH Black and NH White participants had good\/very good prognosis, defined as having a pre\u2010ITI peak inhibitor of\u00a0&lt;\u00a0200 Bethesda Units per millilitre. Nearly 60% of participants (59.7%) achieved successful ITI, 20.7% and 19.5% experienced partially successful or failed ITI, respectively. Successful ITI was non\u2010significantly lower in NH Black (54.2%; aPR\u00a0=\u00a00.95, 95% CI 0.62\u20131.44) and Hispanic (55.4%; aPR\u00a0=\u00a00.89, 95% CI 0.71\u20131.13) relative to NH White participants (62.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, 60% of participants in the CC Registry had successful ITI, consistent with previous studies. The proportion with successful ITI was generally comparable across racial and ethnic groups with similar prognosis. These findings do not support the hypothesis that ITI response varies according to race or ethnicity.\u00a0\u00a0<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14980","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T06:25:01Z","timestamp":1710138301000},"page":"628-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Race and ethnicity and the success of immune tolerance induction among people with severe haemophilia A in the United States"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-6382","authenticated-orcid":false,"given":"Stacey A.","family":"Fedewa","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-2016","authenticated-orcid":false,"given":"Christine L.","family":"Kempton","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00780.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12621"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.12.017"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102251"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6905a1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13734"},{"key":"e_1_2_10_10_1","unstructured":"Food And Drug Administration.FDA approves new treatment to prevent bleeding in certain patients with hemophilia A.2017.https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010approves\u2010new\u2010treatment\u2010prevent\u2010bleeding\u2010certain\u2010patients\u2010hemophilia"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-369132"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13762"},{"key":"e_1_2_10_13_1","unstructured":"ZdebM.Driving Distances and Times Using SAS\u00ae and Google Maps.2010. >. 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