{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:32:29Z","timestamp":1761291149946,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008484","name":"BioMarin Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The physical pain and disability affecting many people with haemophilia A (PwHA) are known detractors from psychological wellbeing. While psychosocial support is considered a core tenet of the haemophilia comprehensive care structure, the extent to which mental health challenges are detected and monitored by the individuals treating haematologist remains relatively unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe prevalence of anxiety and depression in a real\u2010world cohort of adult PwHA and evaluate the congruence in reporting of anxiety or depression (A\/D) between PwHA and their treating physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data for PwHA without inhibitors was drawn from the European \u2018Cost of Haemophilia: A Socioeconomic Survey II\u2019 (CHESS II) study. Haematologist\u2010indicated comorbidities of anxiety and depression were unified into a single A\/D indicator. The EQ\u20105D\u20105L health status measure was used to characterise self\u2010reported A\/D, with individuals stratified into two non\u2010mutually exclusive subgroups based on level of A\/D reported (Subgroup A: \u2018some\u2019 or above; Subgroup B: \u2018moderate\u2019 or above).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Of 381 PwHA with evaluable EQ\u20105D\u20105L responses, 54% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0206) self\u2010reported at least some A\/D (Subgroup A) and 17% (<jats:italic>n<\/jats:italic>\u00a0=\u00a066) reported at least moderate A\/D (Subgroup B). Patient\u2010physician congruence in A\/D reporting was 53% and 76% for Subgroups A and B, respectively. Descriptive analysis suggested that individuals with physician\u2010 and\/or self\u2010reported A\/D experienced worse clinical outcomes (bleeding events, joint disease, chronic pain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While adverse clinical outcomes appear to correlate with A\/D, self\u2010reports of moderate\u2013severe symptoms occasionally lacked formal recognition from treating physicians. Cross\u2010disciplinary surveillance of mental health issues could improve both psychological and clinical outcomes among PwHA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14989","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T15:53:35Z","timestamp":1710950015000},"page":"743-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anxiety and depression among adults with haemophilia A: Patient and physician reported symptoms from the real\u2010world European CHESS II study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-0260","authenticated-orcid":false,"given":"Enrico","family":"Ferri Grazzi","sequence":"first","affiliation":[{"name":"Health Economics and Outcomes Research HCD Economics Knutsford 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