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Although the clear\u2010cut association between low clotting factor levels and risk of bleeding is well recognised, a relationship between high levels, some non\u2010factor therapies and thrombotic risk also exists. The management of thrombosis in persons with inherited bleeding disorders is complex but manageable with modern treatments and collaboration in decision making between health care professionals and patients. Despite the improvements in treatment and reduction in bleeding, mostly musculoskeletal pain continues to be a major issue with advancing age. The management of pain amongst older people with haemophilia who may have multiple comorbidities should involve a person\u2010centred, holistic, multi\u2010disciplinary approach to support and optimise long\u2010term physical functioning and overall quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14994","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:25:13Z","timestamp":1711599913000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Challenges in ageing persons with haemophilia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-7939","authenticated-orcid":false,"given":"Michael","family":"Makris","sequence":"first","affiliation":[{"name":"School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-3094","authenticated-orcid":false,"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[{"name":"Helsinki University Hospital, Department of Haematology Coagulation Disorders Unit Comprehensive Cancer Centre Faculty of Medicine Research Program Unit in Systems Oncology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-8022","authenticated-orcid":false,"given":"Megan","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Discipline of Physiotherapy School of Medicine University of Dublin Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.088088"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04256.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005843"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.020"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14343"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904377"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00038.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.102193"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18085"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005260"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.05.009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00906.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.07.005"},{"key":"e_1_2_12_15_1","unstructured":"EUHASS website. 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