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Here, we review recent advances in the management of acquired haemophilia A (AHA), acquired von Willebrand syndrome (AVWS), and patients with hemostatic abnormalities due to chronic liver disease (CLD). Patients with AHA can now benefit from prophylaxis with emicizumab, a therapeutic antibody that mimics the function of activated coagulation factor VIII. The treatment of AVWS remains challenging in many situations and requires careful consideration of the underlying condition. Haemostatic abnormalities in CLD are often compensated by proportional reduction in pro and anti\u2010haemostatic factors resulting in sustained or even increased thrombin generation. Consequently, bleeding in CLD is rarely caused by haemostatic failure and infusion of plasma or coagulation factor concentrates may not be effective.<\/jats:p>","DOI":"10.1111\/hae.14995","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T07:34:03Z","timestamp":1712043243000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acquired bleeding disorders"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-8536","authenticated-orcid":false,"given":"Andreas","family":"Tiede","sequence":"first","affiliation":[{"name":"Department of Haematology, Hemostasis, Oncology, and Stem Cell Transplantation Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Susen","sequence":"additional","affiliation":[{"name":"Hemostasis and Transfusion Department University of Lille, Lille University Hospital  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-7140","authenticated-orcid":false,"given":"Ton","family":"Lisman","sequence":"additional","affiliation":[{"name":"Surgical Research Laboratory and Section of Hepatobiliary Surgery and Liver Transplantation Department of Surgery University of Groningen University Medical Centre Groningen  Groningen The 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