{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:11:22Z","timestamp":1789661482729,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The healthcare systems in Asia vary greatly due to the socio\u2010economic and cultural diversities which impact haemophilia management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An advisory board meeting was conducted with experts in haemophilia care from Asia to understand the heterogeneity in clinical practices and care provision in the region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The overall prevalence of haemophilia in Asia ranges between 3 and 8.58\/100,000 patients. Haemophilia A was more prevalent as compared to haemophilia B with a ratio of around 5:1. There is under\u2010diagnosis in the region due to lack of diagnosis, registries and\/or lack of appropriate facilities in suburban areas. Most patients are referred to the haematologists by their families or primary care physicians, while some are identified during bleeding episodes. Genetic testing faces obstacles like resource constraints, services available at limited centres and unwillingness of patients to participate. Prophylaxis is offered for people with haemophilia (PWH) with a severe bleeding phenotype. Recombinant factors are approved in most countries across the region and are the preferred therapy. The challenges highlighted for not receiving a high standard of care include patients\u2019 reluctance to use an intravenous treatment, poor patient compliance due to frequency of infusions, budget constraints and lack of funding, insurance, availability and accessibility of factor concentrates. Prevalence of neutralizing antibodies ranged from 5% to 20% in the region. Use of immune tolerance induction and bypassing agents to treat inhibitors depends on their cost and availability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haemophilia care in Asia has evolved to a great extent. However, some challenges remain for which a strategic approach along with multi\u2010stakeholder involvement are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14998","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T04:33:27Z","timestamp":1711341207000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Haemophilia care in Asia: Learning from clinical practice in some Asian countries"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-3485","authenticated-orcid":false,"given":"Pantep","family":"Angchaisuksiri","sequence":"first","affiliation":[{"name":"Department of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilou","family":"Amurao\u2010Abiera","sequence":"additional","affiliation":[{"name":"Philippine Children's Medical Center Cancer and Hematology Division (Head)  Quezon City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Chien","family":"Chou","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pol","family":"Chewcharat","sequence":"additional","affiliation":[{"name":"Medical Affairs Manager Pfizer Thailand  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novie Amelia","family":"Chozie","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology Department of Child Health Science Dr. Cipto Mangunkusumo Hospital\/Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Gomez","sequence":"additional","affiliation":[{"name":"Emerging Asia Cluster Medical Lead \u2013 Rare Disease Pfizer Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Sim","family":"Leng","sequence":"additional","affiliation":[{"name":"Director, Haemophilia Centre Department of Haematology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-3010","authenticated-orcid":false,"given":"Pei\u2010Chin","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics Kaohsiung Medical University Hospital; Department of Pediatrics, School of Post\u2010Baccalaureate Medicine College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Mai","sequence":"additional","affiliation":[{"name":"Hemophilia Centre National Institute of Hematology and Blood Transfusion  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulaiha","family":"Muda","sequence":"additional","affiliation":[{"name":"Paediatric Haematology Oncology Unit Hospital Tunku Azizah Women Children Hospital  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-7957","authenticated-orcid":false,"given":"Tulika","family":"Seth","sequence":"additional","affiliation":[{"name":"Professor Hematology AIIMS  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-3482","authenticated-orcid":false,"given":"Darintr","family":"Sosothikul","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society, Bangkok and Integrative and Innovative Hematology\/Oncology Research Unit Faculty of Medicine, Chulalongkorn  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Siu\u2010Ming Wong","sequence":"additional","affiliation":[{"name":"Division of Haematology Department of Medicine &amp; Therapeutics Prince of Wales Hospital The Chinese University of Hong Kong  Hong Kong Hong Kong"},{"name":"Sir YK Pao Centre for Cancer Faculty of Medicine The Chinese University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000278\u2010x"},{"key":"e_1_2_15_3_1","unstructured":"MehtaP ReddivariA.Hemophilia: In: StatPearls year. 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