{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:34:55Z","timestamp":1792172095061,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015758","name":"Novo Nordisk Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Studies of treatment preferences in haemophilia have been conducted in many countries. This study is the first to examine treatment characteristic preferences among people with haemophilia (PWH) and their caregivers, and physicians in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine current treatment preferences of PWH and their caregivers, plus those of physicians at haemophilia treatment centres (HTCs) and non\u2010HTCs for different treatment characteristics in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Physicians listed on a survey panel were invited to participate in the survey and to refer PWH and caregivers to participate in the survey. Web\u2010based surveys were conducted to examine physician and PWH\/caregiver background, prophylaxis background, prophylaxis goals, understanding of haemophilia treatment products, important information sources, preferences while choosing prophylaxis products, understanding of the patient's condition, and potential product switching. A discrete choice experiment exercise was included in the survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 107 physicians and 44 PWH\/caregivers participated in the study. Key treatment goals of physicians included optimisation of haemophilia management. PWH\/caregivers were focused on quality of life and reduced treatment burden. Consistent differences in haemophilia treatment strategies at HTCs and non\u2010HTCs were observed for prescribed treatments, preferences in choosing prophylaxis products, understanding of patients\u2019 condition, and reasons for potential product switch.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study utilises real\u2010world survey data and presents preferences for haemophilia treatment characteristics among physicians, PWH and their caregivers in Japan, which could encourage improvements in individualised treatment and disease management. Alignment between treatment approaches at HTCs and non\u2010HTCs could facilitate improvements in the quality of care for PWH across Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15028","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:19:35Z","timestamp":1714652375000},"page":"914-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Preference of treatment characteristics among people with haemophilia or their caregivers, and physicians in the Japanese healthcare environment"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6959-6346","authenticated-orcid":false,"given":"Teruhisa","family":"Fujii","sequence":"first","affiliation":[{"name":"Division of Transfusion Medicine, Hemophilia Treatment Center Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Ishimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medical Sciences Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Takao","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Novo Nordisk Pharma Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Novo Nordisk Pharma Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e2707"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15444"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12314"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14531"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S252580"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00760-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S151812"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14037"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02401.x"},{"key":"e_1_2_10_12_1","first-page":"1687","article-title":"Patient and parent preferences for characteristics of prophylactic treatment in hemophilia","volume":"9","author":"Furlan R","year":"2015","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14119"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14185"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S92985"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14383"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2020.02.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13322"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13221"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13754"},{"issue":"3","key":"e_1_2_10_22_1","first-page":"287","article-title":"Collaborative care of patients with hemophilia in Japan","volume":"56","author":"Shirahata A","year":"2019","journal-title":"Jpn J Pediatr Hemat Oncol"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2491\/jjsth.24.619"},{"key":"e_1_2_10_24_1","unstructured":"Japan Foundation for AIDS Prevention.Report of the 2019 nationwide survey of blood coagulation disorders.Commissioned by the Japanese Ministry of Health Labour and Welfare.2020."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12825"},{"key":"e_1_2_10_26_1","unstructured":"Sawtooth Software SSI Web version 7.0 [computer program]. 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