{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:11:06Z","timestamp":1790349066750,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012112","name":"Swedish Orphan Biovitrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment options for people with haemophilia are evolving at a rapid pace and a range of prophylactic treatment options using various technologies are currently available, each with their own distinct safety and efficacy profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment goals<\/jats:title><jats:p>The access to replacement therapy and prophylaxis has driven a dramatic reduction in mortality and resultant increase in life expectancy. Beyond this, the abolition of bleeds and preservation of joint health represent the expected, but rarely attained, goals of haemophilia treatment and care. These outcomes also do not address the complexity of health\u2010related quality of life impacted by haemophilia and its treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Capitalizing on the major potential of therapeutic innovations, \u2018Normalization\u2019 of haemostasis, as a concept, should include the aspiration of enabling individuals to live as normal a life as possible, free from haemophilia\u2010imposed limitations. To achieve this\u2014being supported by the data reviewed in this manuscript\u2014the concept of haemostatic and life Normalization needs to be explored and debated within the wider multidisciplinary teams and haemophilia community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15031","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:40:45Z","timestamp":1720662045000},"page":"1109-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Moving towards Normalization of haemostasis and health equity: Evolving treatment goals for haemophilia A"],"prefix":"10.1111","volume":"30","author":[{"given":"P\u00e5l Andr\u00e9","family":"Holme","sequence":"first","affiliation":[{"name":"Department of Haematology Oslo University Hospital and Institute of Clinical Medicine University of Oslo  Oslo 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