{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T18:40:04Z","timestamp":1744569604569,"version":"3.40.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Web\u2010Accessible Population\u2013Pharmacokinetic Service\u2013Haemophilia (WAPPS\u2010Hemo) data are available to study factor\u2010concentrate usage, defined as the required weekly dose to achieve a 3% trough (WD3T), across standard and extended half\u2010life (SHL\/EHL) products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide baseline usage data including (i) differences across plasma\u2010derived (pdSHL) versus recombinant (rSHL) products, (ii) SHL versus EHL, and (iii) effect of age and positive inhibitor history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PK profiles (<jats:italic>n<\/jats:italic>\u00a0=\u00a014,416 patients, 0.3\u201385.2\u00a0years) and linear mixed effects models were used to estimate usage versus age, controlling for significant factors, using 95% confidence intervals to perform comparisons across all ages and posthoc tests to assess the differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average usage was significantly higher for pdSHL versus rSHL in patients with a positive inhibitor history (PIH; 1.9\u20132.5 times higher), for SHL versus EHL (4\u201310 times), and was significantly associated with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baseline usage patterns from 2017 to early 2023 provide a benchmark for assessing the impact of emerging technologies in haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15032","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:39:20Z","timestamp":1715607560000},"page":"925-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimated prophylactic dose required to achieve 3% trough as a function of age and concentrate class in multi\u2010country severe WAPPS\u2010Hemo haemophilia patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Dagmar M.","family":"Hajducek","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Waterloo  Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-4774","authenticated-orcid":false,"given":"Pierre","family":"Chelle","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Waterloo  Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Health Evidence and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Iserman","sequence":"additional","affiliation":[{"name":"Department of Health Evidence and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-1653","authenticated-orcid":false,"given":"Andrea N.","family":"Edginton","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Waterloo  Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1111\/j.1365-2516.2008.01664.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1182\/blood-2012-12-470898"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1111\/hae.13977"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.2196\/resprot.6558"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1137\/0916069"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1111\/j.1365-2516.2001.00530.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1055\/s-0037-1613191"},{"issue":"4","key":"e_1_2_10_9_1","first-page":"494","article-title":"Factor VIII half\u2010life and clinical phenotype of severe hemophilia A","volume":"90","author":"Van Dijk K","year":"2005","journal-title":"Haematologica"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1046\/j.1365-2516.2003.00780.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1111\/hae.14329"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.thromres.2018.08.004"},{"key":"e_1_2_10_13_1","article-title":"Report on the annual global survey","author":"Hemophilia WFo","year":"2021","journal-title":"World Federation of Hemophilia"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.15032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T18:08:40Z","timestamp":1744567720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.15032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/hae.15032"],"URL":"https:\/\/doi.org\/10.1111\/hae.15032","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2024,5,13]]},"assertion":[{"value":"2023-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}