{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:35:22Z","timestamp":1784010922548,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Gastrointestinal (GI) bleeding events (BEs) in von Willebrand disease (VWD) are difficult to diagnose and often recurrent. Limited data from clinical trials has led to lack of consensus on treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Describe current treatments and outcomes for GI BEs in people with VWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, observational, multicentre chart review study was conducted from January 2018 through December 2019 and included patients with inherited VWD with \u22651 GI BE in the preceding 5\u00a0years. Baseline characteristics, number and aetiology of BEs, associated GI\u2010specific morbidities\/lesions, treatment and outcomes were analysed descriptively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty bleeds were reported in 20 patients with type 1 (20%), type 2 (50%) and type 3 (30%) VWD. During the 5\u2010year study period, 31 (52%) BEs had one identified or suspected cause; multiple causes were reported in 11 (18%). Most GI BEs (72%) were treated with a combination of von Willebrand factor (VWF), antifibrinolytics and\/or other haemostatic or non\u2010haemostatic treatments. Time to resolution did not differ by VWF treatment use; however, BEs treated with non\u2010VWF treatments tended to resolve later. In patients with GI\u2010specific morbidities\/lesions, 84% resolved with first\u2010line treatment; time to resolution tended to be longer than in patients without such morbidities\/lesions. Thirteen BEs occurred in patients receiving prophylaxis and 47 in patients receiving on\u2010demand treatment; 18 BEs resulted in a switch to prophylaxis after bleed resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms the unmet need for the management of recurrent GI BEs in people with VWD and the need for prospective data, especially on prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15034","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T04:23:41Z","timestamp":1715833421000},"page":"970-980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective chart review of GI bleeding in people with von Willebrand disease"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-9543","authenticated-orcid":false,"given":"Jonathan C.","family":"Roberts","sequence":"first","affiliation":[{"name":"Bleeding &amp; Clotting Disorders Institute, Dills Family Foundation Center for Research at BCDI Peoria Illinois USA"},{"name":"Departments of Pediatrics and Medicine University of Illinois College of Medicine at Peoria  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-0240","authenticated-orcid":false,"given":"Miguel A.","family":"Escobar","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra","family":"Acharya","sequence":"additional","affiliation":[{"name":"Northwell Health Hemostasis and Thrombosis Center Cohen Children's Medical Center Zucker School of Medicine at Hofstra\/Northwell  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina X.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Inherited Blood Disorders CHOC Children's Hospital  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wang","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center University of Colorado, Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hale","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals U.S.A., Inc.  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