{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:58:27Z","timestamp":1778021907730,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objectives were to describe the peri\u2010operative management of people with inherited bleeding disorders in oral surgery and to investigate the association between type of surgery and risk of developing bleeding complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This retrospective observational study included patients with haemophilia A or B, von Willebrand disease, Glanzmann thrombasthenia or isolated coagulation factor deficiency such as afibrinogenemia who underwent osseous (third molar extraction, ortho\u2010surgical traction, dental implant placement) or nonosseous oral surgery between 2014 and 2021 at Bordeaux University Hospital (France). Patients and oral surgery characteristics were retrieved from medical records. Odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 83 patients included, general anaesthesia was performed in 16%. Twelve had a bleeding complication (14.5%) including six after osseous surgery. The most serious complication was the appearance of anti\u2010FVIII inhibitor in a patient with moderate haemophilia A. All bleeding complications were managed by a local treatment and factor injections where indicated. No association was observed between type of surgery (osseous vs. nonosseous) and risk of bleeding complications after controlling for sex, age, disease type and severity, multiple extractions, type of anaesthesia and use of fibrin glue (OR: 3.21, 95% CI:\u00a0.69\u201314.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we have observed that bleeding complications after oral surgery in people with inherited bleeding disorders were moderately frequent and easily managed. However, in this study, we observed a serious complication highlighting the necessity of a thorough benefit\u2010risk balance evaluation during the preoperative planning of the surgical and medical protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15055","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T04:39:22Z","timestamp":1717389562000},"page":"943-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral surgery in people with inherited bleeding disorder: A retrospective study"],"prefix":"10.1111","volume":"30","author":[{"given":"Emma","family":"Fribourg","sequence":"first","affiliation":[{"name":"Oral Surgery Department CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Castet","sequence":"additional","affiliation":[{"name":"Biological Hematology Department CHU Bordeaux, Resource and Competence Center for Constitutional Hemorrhagic Disorders  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"F\u00e9nelon","sequence":"additional","affiliation":[{"name":"Oral Surgery Department CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoann","family":"Huguenin","sequence":"additional","affiliation":[{"name":"Biological Hematology Department CHU Bordeaux, Resource and Competence Center for Constitutional Hemorrhagic Disorders  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Christophe","family":"Fricain","sequence":"additional","affiliation":[{"name":"Oral Surgery Department CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Chuy","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Bucco\u2010Dentaire CHU Bordeaux Bordeaux France"},{"name":"Univ Bordeaux, INSERM, BPH  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-3467","authenticated-orcid":false,"given":"Sylvain","family":"Catros","sequence":"additional","affiliation":[{"name":"Oral Surgery Department CHU Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12344"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"Gestion p\u00e9ri\u2010op\u00e9ratoire des patients trait\u00e9s par antithrombotiques en chirurgie orale. Argumentaire. M\u00e9decine Buccale Chir Buccale.2015;21:S15\u201081.","DOI":"10.1051\/mbcb\/2015037"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029616658116"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.03.016"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2001.tb00272.x"},{"key":"e_1_2_10_7_1","unstructured":"RESERVES IUTD. Orphanet: Maladie de von Willebrand [Internet]. [cit\u00e9 11 d\u00e9c 2022]. Disponible sur:https:\/\/www.orpha.net\/consor\/cgi\u2010bin\/OC_Exp.php?Lng=FR&Expert=903"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"127","article-title":"Hemophilia and oral health","volume":"16","author":"Zaliuniene R","year":"2014","journal-title":"Stomatologija"},{"key":"e_1_2_10_9_1","unstructured":"KrauseKA GrahamBC.Glanzmann Thrombasthenia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 [cit\u00e9 6 juill 2021]. Disponible sur:http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538270\/"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00423.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1051\/mbcb\/2015013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.071"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19191"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01132.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14609"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.04.016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02346.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-014-0476-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13928"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/ID.0000000000000821","article-title":"Dental implant therapy on a patient with von willebrand disease","author":"michael Kang","year":"2018","journal-title":"Implant Dent"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1722866"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-229204"},{"key":"e_1_2_10_24_1","article-title":"Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions","volume":"4","author":"Galen KP","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"e_1_2_10_25_1","first-page":"40","article-title":"The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders","volume":"29","author":"Ak G","year":"2012","journal-title":"Turk J Haematol Off J Turk Soc Haematol"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100020"},{"issue":"7","key":"e_1_2_10_27_1","first-page":"488","article-title":"Dental extractions in patients with mild hemophilia A and hemophilia B and von Willebrand disease without clotting factor supplementation","volume":"128","author":"Lewandowski B","year":"2018","journal-title":"Pol Arch Intern Med"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.15055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T18:08:37Z","timestamp":1744567717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.15055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,2]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/hae.15055"],"URL":"https:\/\/doi.org\/10.1111\/hae.15055","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,2]]},"assertion":[{"value":"2023-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}