{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:22:58Z","timestamp":1769721778786,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Physical therapy benefits patients with haemophilia (PWH), but its impact on the health\u2010related quality of life (HRQOL) remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This systematic review and meta\u2010analysis investigated the association of physical therapy, including therapeutic exercise, manual therapy, and physical agent modality, with HRQOL improvement in PWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases PubMed, Embase, MEDLINE, and Scopus were searched from inception until April 2024. This review included randomised controlled trials (RCTs) that compare the HRQOL between the physical therapy and control groups. Relevant data and outcome values of included study were collected. Cochrane collaboration's tool and the grading of recommendations, assessment, development, and evaluation approach were used for risk of bias (ROB) and evidence\u2010level assessment, individually.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The systematic review included eight RCTs that involved 298 male PWH. The meta\u2010analysis for HRQOL improvement revealed a significant difference in favour of physical therapy (standardised mean difference [SMD]\u00a0=\u00a0.92; 95% confidence interval [CI]:.50\u20131.33; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Therapeutic exercise exhibited more benefits in HRQOL improvement than the control groups (SMD\u00a0=\u00a01.02; 95% CI:.49\u20131.55; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Physical therapy effectively improved HRQOL in PWH with better joint status (SMD\u00a0=\u00a01.74; 95% CI:.97\u20132.51; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Of the eight RCTs, six were rated as high ROB. The comparisons revealed a moderate certainty of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physical therapy, especially therapeutic exercise, effectively improved the HRQOL of PWH. Maintaining better joint status and timely physical therapy intervention is crucial for HRQOL improvements in PWH. Cautious interpretation is required due to evidence limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.15120","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T07:59:20Z","timestamp":1735027160000},"page":"16-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of physical therapy on health\u2010related quality of life in patients with haemophilia: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-0096","authenticated-orcid":false,"given":"Chien\u2010Min","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital  Chiayi Taiwan"},{"name":"School of Medicine College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Ching","family":"Shie","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital  Chiayi Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.27"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00116-O"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb05381.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-021-01273-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2010.489933"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01144.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2023.279613"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13025"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12644"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130108"},{"key":"e_1_2_11_12_1","first-page":"577","article-title":"Joint range of motion, joint health, strength, and mobility in patients with hemophilia: a systematic review and meta\u2010analysis","volume":"102","author":"Chen CM","year":"2023","journal-title":"Phys Ther Joint Pain"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2022.05.023"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13900"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.10.014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2021.12.023"},{"key":"e_1_2_11_17_1","first-page":"11","article-title":"Do therapeutic exercises improve kinesophobia and health\u2010related quality of life in adult hemophilia patients? A randomized controlled trial","volume":"3","author":"Deniz V","year":"2020","journal-title":"Int J of Disabil Sports Health Sci"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/abr.abr_244_18"},{"key":"e_1_2_11_19_1","first-page":"70","article-title":"Effects of short\u2010term aerobic, resistance and combined exercises on the lipid profiles and quality of life in overweight individuals with moderate hemophilia A: a randomized controlled trial","volume":"35","author":"Parhampour B","year":"2021","journal-title":"Med J Islam Repub Iran"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13079"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14281"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60903-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12690"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4817"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0429-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.15067"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14498"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139690"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273355"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2008.03.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.11648\/j.ajhr.20130103.13"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.15120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:21:37Z","timestamp":1738214497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.15120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/hae.15120"],"URL":"https:\/\/doi.org\/10.1111\/hae.15120","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}