{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:53:27Z","timestamp":1772999607071,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemarthrosis, particularly in the knee, accounts for most bleeding episodes in haemophilia. While joint aspiration has proven effective, the role of intra\u2010articular (IA) tranexamic acid (TXA) in managing acute hemarthrosis remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy and safety of knee aspiration followed by IA TXA injection in acute haemophilic knee hemarthrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four adult haemophilia patients with acute knee hemarthrosis (&lt; 24 h) were randomized to undergo joint aspiration with (TXA group) or without (non\u2010TXA group) IA TXA (1.5\u00a0g\/15\u00a0mL) injection. Both groups received 75\u00a0mL injections, including 5\u00a0mL of 2% lidocaine and additional 0.9% saline. Ultrasound confirmed hemarthrosis, and standardized factor replacement was given pre\u2010procedure. Primary outcomes included knee range of motion (ROM) and visual analogue scale (VAS) for pain. The significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Final analysis included 21 and 17 male patients in the TXA and non\u2010TXA groups, respectively. The TXA group showed a significantly greater knee ROM on days 3, 7, and 14 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), with no differences beyond Day 14. VAS pain scores were significantly lower in the TXA group at 24 h, 3 days, and 7 days post\u2010procedure (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). TXA patients reported faster return to work (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and higher satisfaction (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). Hemarthrosis recurrence was lower in the TXA group (5.9%\u00a0vs. 14.3% at 6 weeks; 64.7%\u00a0vs. 90.5% at 6 months), though differences were not statistically significant. No complications were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Joint aspiration with IA TXA is safe and effective for short\u2010term ROM improvement and pain relief in acute haemophilic knee hemarthrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70000","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:46:28Z","timestamp":1738907188000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Aspiration and Intra\u2010Articular Injection of Tranexamic Acid in Acute Knee Hemarthrosis of Adult Haemophilic Patients: A Randomized Clinical Trial Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-4974","authenticated-orcid":false,"given":"Seyed Hadi","family":"Kalantar","sequence":"first","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-1163","authenticated-orcid":false,"given":"Mohammadreza","family":"Razzaghof","sequence":"additional","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younes","family":"Noshadi","sequence":"additional","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ayati","family":"Firoozabadi","sequence":"additional","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Toogeh","sequence":"additional","affiliation":[{"name":"Thrombosis Hemostasis Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeyran","family":"Zebardast","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katayoon","family":"Karimi","sequence":"additional","affiliation":[{"name":"Thrombosis Hemostasis Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9140-2560","authenticated-orcid":false,"given":"Behzad","family":"Nejad Tabrizi","sequence":"additional","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-7777","authenticated-orcid":false,"given":"Seyed Mohammad Javad","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"Joint Reconstruction Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Orthopedic Surgery Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran 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