{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:01:46Z","timestamp":1782302506084,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Haemophilia management aims to prevent bleeding and preserve joint function. Changes in patients\u2019 joint health may influence physicians' decisions to adjust treatment. The Haemophilia Joint Health Score (HJHS) and Haemophilia Early Arthropathy Detection with Ultrasound (HEAD\u2010US) score assess joint health but are not routinely used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate whether systematic joint examination with HJHS and\/or HEAD\u2010US had an impact on treatment management decisions in France, using final data from the A\u2010MOVE study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A\u2010MOVE (NCT04133883) was a 12\u2010month prospective, multicentre study, which enrolled persons with haemophilia A (all severities, aged 6\u201340 years) treated prophylactically or on demand with standard\/extended half\u2010life FVIII replacement. At baseline, 6 and 12 months, HJHS\/HEAD\u2010US and changes in patients\u2019 management were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six patients from 20 sites were included in the final analysis; 68 had HJHS\/HEAD\u2010US assessments at 12 months. Over 12 months, 24.4% (\n                      <jats:italic>n<\/jats:italic>\n                      = 21\/86) of patients experienced an impact on their haemophilia management due to HJHS\/HEAD\u2010US scores; these decisions were impacted by HJHS in about half of the patients (52.4%,\n                      <jats:italic>n<\/jats:italic>\n                      = 11\/21) and HEAD\u2010US in almost all patients (95.2%,\n                      <jats:italic>n<\/jats:italic>\n                      = 20\/21). Both assessments contributed to a change in management decisions in about half of the patients (47.6%,\n                      <jats:italic>n<\/jats:italic>\n                      = 10\/21). Twenty\u2010nine patients (33.7%) had haemophilia management decisions impacted by factors other than HJHS\/HEAD\u2010US, including physical examination findings (\n                      <jats:italic>n<\/jats:italic>\n                      = 9) and the occurrence of bleeding episodes (\n                      <jats:italic>n<\/jats:italic>\n                      = 8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Final data from the A\u2010MOVE study show that systematic joint assessments, through functional\/physical examination (HJHS) and ultrasound (HEAD\u2010US), may impact treatment management decisions in persons with haemophilia A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70012","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:42:53Z","timestamp":1741718573000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Systematic Joint Examination (Ultrasound, Functional and Physical) on Treatment Management Decisions in Patients With Haemophilia A in France: Final Data From the Prospective, Observational A\u2010MOVE Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-5190","authenticated-orcid":false,"given":"Nicolas","family":"Drillaud","sequence":"first","affiliation":[{"name":"CRC\u2010MHC Haemophilia Treatment Centre University Hospital  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Barbay","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre University Hospital of Rouen Normandie  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Baptiste","family":"Valentin","sequence":"additional","affiliation":[{"name":"CRC\u2010MHC Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Jailler","sequence":"additional","affiliation":[{"name":"CRC\u2010Centre Hospitalier M\u00e9tropole Savoie  Chamb\u00e9ry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-0427","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Lebreton","sequence":"additional","affiliation":[{"name":"Centre de Ressource et de Comp\u00e9tence des Maladies H\u00e9morragiques Constitutionnelles CHU Clermont\u2010Ferrand H\u00f4pital Estaing  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Pan\u2010Petesch","sequence":"additional","affiliation":[{"name":"CRC\u2010MHC Brest \u2013 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