{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:38:37Z","timestamp":1792654717761,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Data regarding long\u2010term clinical outcomes in Asian patients with acquired haemophilia A (AHA) was limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of current treatments and their outcomes in a real\u2010world setting among Thai patients with AHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study conducted at a university\u2010based hospital. Patients\u2019 characteristics, treatment patterns and disease outcomes were collected. Univariate and multivariate Gray's competing risk analyses were used to examine the factors related to the time to disease response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2009 to 2022, 69 AHA patients with a median age of 68 years (range 36\u201397) were enrolled. The majority of cases were characterised by the absence of an underlying aetiology (82.6%) and presented as major bleeding (71.0%). As first\u2010line treatment, 79.7% were treated with steroid monotherapy, and 13.0% received a combination of steroid and rituximab. Thirty\u2010one patients (44.9%) received at least one dose of haemostatic agents. After a median time to follow\u2010up of 24.9 months (interquartile range 1.6\u201378.5), 41 patients (59.4%) attained first disease remission. Factor VIII below 1\u00a0IU\/dL and the combination of steroid and rituximab were associated with time to disease remission, with subdistribution hazard ratio of 0.3 (95% confidence interval [CI], 0.1\u20130.7) and 5.2 (95% CI, 2.0\u201313.4), respectively. The most common complication in this cohort was infection (40.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of steroid and rituximab demonstrated efficacy in the management of AHA. In addition, infectious complications were a significant concern when treating AHA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70028","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:30:17Z","timestamp":1742275817000},"page":"412-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Treatment Patterns and Long\u2010Term Clinical Outcomes in Thai Patients With Acquired Haemophilia A"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-9992","authenticated-orcid":false,"given":"Nonthakorn","family":"Hantrakun","sequence":"first","affiliation":[{"name":"Division of Hematology Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai 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