{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:27:39Z","timestamp":1791656859158,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Glanzmann's thrombasthenia (GT) is an inherited platelet function disorder that may manifest with significant bleeding symptoms; in women and girls (W&amp;Gs), heavy menstrual bleeding (HMB) is very common. GT in pregnancy is associated with an increased risk of postpartum haemorrhage (PPH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study highlights the gynaecological and obstetric challenges experienced by W&amp;Gs with GT, and reviews available treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data regarding 38 W&amp;Gs with GT were analysed from the ISTH REDCap registry, an international multi\u2010centre database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 38 W&amp;Gs, 76% of Middle Eastern ethnicity, 100% reported HMB; 92% HMB since menarche, and 82% presented with acute HMB and were treated with platelets and packed red blood cells (pRBCs) transfusions in addition to hormonal therapies. Management of chronic HMB required a combination therapy including antifibrinolytics (tranexamic acid [TXA]), hormonal therapies, and recombinant factor VIIa (rFVIIa); rFVIIa was used in 50% of W&amp;Gs. In 16 pregnancies, PPH was reported in 63% of deliveries, of which 83% required blood and platelet transfusions. Despite prophylactic haemostatic agents during labour and delivery in 8\/9 pregnancies of women with known GT diagnosis, 78% experienced PPH. Thirty\u2010one percent of neonates developed neonatal alloimmune thrombocytopenia (NAIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HMB and PPH are common bleeding complications in GT. Effective management of HMB and PPH in W&amp;Gs with GT is challenging but can be achieved by a multidisciplinary team, often requiring a combination of haemostatic agents with hormonal therapies. Use of rFVIIa may limit the need for platelet transfusion, thus reducing alloimmunisation and the risk of developing NAIT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70030","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T06:29:21Z","timestamp":1742797761000},"page":"509-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Obstetric and Gynaecological Challenges and Outcomes in Women and Girls With Glanzmann's Thrombasthenia"],"prefix":"10.1111","volume":"31","author":[{"given":"Deborah","family":"Obeng\u2010Tuudah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Katharine Dormandy Haemophilia and Thrombosis Centre, The Royal Free NHS Hospital and Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Tarawah","sequence":"additional","affiliation":[{"name":"Madinah Hereditary Blood Disorders Center King Salman Medical City  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Katharine Dormandy Haemophilia and Thrombosis Centre, The Royal Free NHS Hospital and Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-1006","authenticated-orcid":false,"given":"Rezan","family":"Abdul\u2010Kadir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Katharine Dormandy Haemophilia and Thrombosis Centre, The Royal Free NHS Hospital and Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108805"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.5.841.841"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214239"},{"issue":"23","key":"e_1_2_12_5_1","first-page":"5996","article-title":"Glanzmann Thrombasthenia: A Review of ITGA2B and ITGB3 Defects With Emphasis on Variants, Phenotypic Variability, and Mouse Models","volume":"118","author":"Nurden A. 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