{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:39:01Z","timestamp":1792654741447,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inhibitor development against factor VIII (FVIII) is the most common complication of hemophilia A replacement therapy. One of the variables considered to influence inhibitor development is the ABO blood group. Patients with blood group O have, on average, a 30%\u201340% lower endogenous von Willebrand factor (VWF) concentration. It has been postulated that VWF levels influence inhibitor development. The objective of this study was to investigate the inhibitor risk in patients with severe hemophilia A comparing those with blood group O with those with non\u2010O blood groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study population consisted of children with severe hemophilia A, born between 2000 and 2020, who reached 50 FVIII exposure days in the PedNet registry. Inhibitors were considered to be clinically relevant when at least two consecutive measurements were tested positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Routine testing of blood groups varied between centres: Out of 1172 patients with severe hemophilia A, blood group status was known in 759 patients (65.8%). The relative risk of inhibitor development for blood group O in comparison to non\u2010O was 1.04 (95% CI: 0.7\u20131.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the PedNet cohort, blood group O did not increase the risk of inhibitors in previously untreated children with severe hemophilia A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PedNet Registry; clinicaltrials.gov identifier: NCT02979119<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70035","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T06:42:11Z","timestamp":1742798531000},"page":"419-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood Group O Does Not Increase the Risk of Inhibitors in Severe Haemophilia A: Data from the PedNet Study Group"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-1863","authenticated-orcid":false,"given":"Marloes","family":"de Kovel","sequence":"first","affiliation":[{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e\u2010Claire","family":"van Haaster","sequence":"additional","affiliation":[{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-1763","authenticated-orcid":false,"given":"Manuel","family":"Carcao","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology, Department of Paediatrics The Hospital for Sick Children and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-0371","authenticated-orcid":false,"given":"Susanna","family":"Ranta","sequence":"additional","affiliation":[{"name":"Astrid Lindgren Children\u2019s Hospital Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Glosli","sequence":"additional","affiliation":[{"name":"Centre for Rare Disorders Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-9441","authenticated-orcid":false,"given":"Georges E.","family":"Rivard","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology H\u00f4pital St Justine, Montr\u00e9al  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-2557","authenticated-orcid":false,"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[{"name":"National Hemophilia Center, Sheba Medical Center Tel Hashomer and Amalia Biron Research Institute of Thrombosis and Hemostasis, Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kurnik","sequence":"additional","affiliation":[{"name":"Paediatric Thrombosis and Haemostasis Unit, Paediatric Haemophilia Center Dr. von Hauner Children's Hospital, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Van Geet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Hematology and Oncology University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro de Refer\u00eancia de Coagulopatias Cong\u00e9nitas do Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, EPE  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-8350","authenticated-orcid":false,"given":"Nadine G.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Haemostasis Ska\u030ane University Hospital  Malm\u00f6 Sweden"},{"name":"Department of Paediatric Haematology and Oncology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Clinical Sciences and Paediatrics Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"Kartal\u2010Kaess","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-8747","authenticated-orcid":false,"given":"Rolf","family":"Ljung","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-2324","authenticated-orcid":false,"given":"H. Marijke","family":"van den Berg","sequence":"additional","affiliation":[{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the PedNet Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00780.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-586347"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13731"},{"key":"e_1_2_10_6_1","first-page":"7","article-title":"Risk Factors for Inhibitor Development in Hemophilia A","volume":"85","author":"Oldenburg J.","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284095"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02700.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.05.027"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516437"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218258"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457036"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006745"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12592"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13242"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13437"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15395"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.112821"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718870"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718785363"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12853"},{"key":"e_1_2_10_22_1","unstructured":"NHS Blood Donation [Internet] \u201cBlood Types [Cited 12 August 2024] \u201d accessed August 12 2024.https:\/\/www.blood.co.uk\/why\u2010give\u2010blood\/blood\u2010types\/."},{"key":"e_1_2_10_23_1","unstructured":"Red Cross [Internet] \u201cFacts About Blood and Blood Types [Cited 30 March 2021] \u201d accessed September 28 2021.https:\/\/www.redcrossblood.org\/donate\u2010blood\/blood\u2010types.html."},{"key":"e_1_2_10_24_1","unstructured":"Standford Blood Center [Internet]. \u201cBlood Types [Cited 12 August 2024] \u201d accessed August 12 2024.https:\/\/stanfordbloodcenter.org\/donate\u2010blood\/blood\u2010donation\u2010facts\/blood\u2010types\/."}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:52:43Z","timestamp":1792651963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,23]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/hae.70035"],"URL":"https:\/\/doi.org\/10.1111\/hae.70035","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,23]]},"assertion":[{"value":"2024-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}