{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:55Z","timestamp":1787839195237,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilia is a hereditary bleeding disorder that leads to joint damage and musculoskeletal impairments, affects balance and increases the risk of falls. Although exercise is beneficial, little is known about the clinical effects of programmes that focus on balance and proprioception in people with haemophilia (PwH). The aim of this study is to evaluate the effectiveness of a 12\u2010week multimodal balance and strength training programme (MBSTP) on balance, fall risk, strength, functionality, kinesiophobia and quality of life (QoL) in adult PwH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single\u2010blind non\u2010randomized controlled trial was conducted with 22 PwH (mean age 34.5\u00a0\u00b1\u00a09.2\u00a0years). Participants were assigned to an experimental group (EG,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011), who underwent the MBSTP, or a control group (CG,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011), who continued their usual exercises. Static and dynamic, fall risk, strength and functionality (Time Up and Go, Sit to Stand Test and 2\u2010Minute Walk Test), kinesiophobia and QoL were assessed pre\u2010 and post\u2010intervention, Additionally, the participants\u2019 satisfaction with the programme was measured. Intervention effects were determined with a two\u2010way mixed ANOVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The EG presented significant improvements (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05, with a small to large effect size) in balance (bipodal open eyes in unstable surface and monopodal total\u2010velocity, LoS and subjective perception of balance), functionality, fall risk and strength (quadriceps and gluteus medius) compared to the CG. The EG reported high satisfaction with the programme.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the significant improvements in dynamic balance, lower limb strength, functionality and fall risk reduction, integrating supervised multimodal exercise programmes into routine rehabilitation for PwH could enhance mobility and prevent falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT04122014.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70040","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T21:04:41Z","timestamp":1743368681000},"page":"544-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multimodal Exercise Program of Balance and Strength Improves Dynamic Balance, Strength and Functionality and Decreases the Risk of Falls in Adults With Haemophilia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-0174","authenticated-orcid":false,"given":"Ana","family":"Chimeno\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-5767","authenticated-orcid":false,"given":"Sof\u00eda","family":"P\u00e9rez\u2010Alenda","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-3368","authenticated-orcid":false,"given":"Carlos","family":"Cruz\u2010Montecinos","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Department of Physical Therapy, Faculty of Medicine University of Chile  Santiago Chile"},{"name":"Division of Research, Devolvement and Innovation in Kinesiology, Kinesiology Unit San Jos\u00e9 Hospital  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-3772","authenticated-orcid":false,"given":"Juan. J.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Intelligent Data Analysis Laboratory University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-0662","authenticated-orcid":false,"given":"Marta","family":"Aguilar\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Physiotherapy in Motion, Multispecialty Research Group (PTinMOTION), Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Haemostasis and Thrombosis Unit University and Polytechnic Hospital La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13449"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14025"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.26420\/annhematoloncol.2017.1172"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02514.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13441"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01613.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02110.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12031"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzaa106"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13955"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2017.12.022"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2014.11.012"},{"key":"e_1_2_12_17_1","unstructured":"Aplicaciones NedAMH\/IBV y NedSVE\/IBV e informaci\u00f3n t\u00e9cnica. 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