{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:53:39Z","timestamp":1793210019903,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of point\u2010of\u2010care (POC) ultrasound (US) in detecting joint changes in haemophilic arthropathy compared to comprehensive US, physical examination and MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010centre, prospective study examining 22 ankles, eight knees and nine elbows of 28 subjects (median\/range, 16\/6\u201327\u00a0years) with inherited bleeding disorders. Same\u2010day physical and imaging joint assessment was performed using Haemophilia Joint Health Score (HJHS) 2.1, POC\u2010US, comprehensive US and MRI. Two readers reviewed the imaging studies using standardized scoring systems. The inter\u2010reader agreement was assessed with weighted kappa statistics. Diagnostic test performance of POC\u2010US and comprehensive US was benchmarked against MRI findings using sensitivity, specificity, predictive values and accuracy. Spearman correlation was used to correlate physical examination and imaging findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Moderate inter\u2010reader agreement was observed for soft\u2010tissue changes (kappa\u00a0=\u00a00.58), which was lower than comprehensive US (kappa\u00a0=\u00a00.76) and MRI (kappa\u00a0=\u00a00.77). Agreement for osteochondral lesions was poor (\u03ba 0.09), trailing behind comprehensive US (kappa\u00a0=\u00a00.55) and MRI (kappa\u00a0=\u00a00.75). POC\u2010US showed reduced accuracy across all joint parameters in the elbows and ankles compared to comprehensive US, but comparable diagnostic performance in the knees. A good correlation was noted between total POC\u2010US scores and HJHS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), similar to comprehensive US (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>POC\u2010US is valuable for assessing soft\u2010tissue changes in haemophilic arthropathy, correlates satisfactorily with physical examination, but its accuracy is inferior to comprehensive US for ankles and elbows. Both POC\u2010US and comprehensive US should be employed cautiously for assessing osteochondral joint abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70049","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:52:19Z","timestamp":1747641139000},"page":"787-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Point\u2010of\u2010Care Ultrasound in Paediatric Haemophilic Arthropathy: A Prospective Comparative Study With Comprehensive Ultrasound and MRI"],"prefix":"10.1111","volume":"31","author":[{"given":"Caroline","family":"Rutten","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-7876","authenticated-orcid":false,"given":"Magdy","family":"Soliman","sequence":"additional","affiliation":[{"name":"Research Institute Department of Translational Medicine Peter Gilgan Centre for Research and Learning The Hospital for Sick Children  Toronto ON Canada"},{"name":"Department of Radiology Russells Hall Hospital  Dudley England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Panwar","sequence":"additional","affiliation":[{"name":"Research Institute Department of Translational Medicine Peter Gilgan Centre for Research and Learning The Hospital for Sick Children  Toronto ON Canada"},{"name":"Department of Medical Imaging Tweed Hospital  Tweed Heads New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Mohanta","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Hilliard","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Rayner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"University of Toronto  Toronto Ontario 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