{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:27:26Z","timestamp":1773008846179,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>RVIII\u2010SingleChain is a B\u2010domain\u2010truncated factor VIII construct with a covalent bond between the factor VIII heavy and light chains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We report on the efficacy and safety of rVIII\u2010SingleChain in subjects with severe haemophilia A undergoing surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Surgery, elective or emergent, was defined as all procedures requiring general, spinal, or regional anaesthesia. rVIII\u2010SingleChain was administered as a bolus or continuous infusion during the perioperative period, dosed individually at the discretion of the investigator based upon the type of surgery and clinical status of the patient. The investigator rated haemostatic efficacy on a 4\u2010point scale (excellent, good, moderate or poor\/no response), where treatment success was defined as excellent or good.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 36 subjects underwent 48 surgeries: 41 surgeries in 30 adult\/adolescent (mean age 34 [range 12\u201364] years) and 7 in 6 paediatric subjects (mean age 8 [5\u201311] years). rVIII\u2010SingleChain was administered during 24 orthopaedic and 17 non\u2010orthopaedic surgeries in adults\/adolescents and 7 non\u2010orthopaedic surgeries in paediatrics. Haemostatic efficacy was rated as excellent (\n                      <jats:italic>n<\/jats:italic>\n                      = 36, 88%) or good (\n                      <jats:italic>n<\/jats:italic>\n                      = 5, 12%) in adult\/adolescent surgeries and as excellent (\n                      <jats:italic>n<\/jats:italic>\n                      = 7, 100%) in paediatric surgeries. In adults\/adolescents, mean (standard deviation [SD]) blood loss was lower than predicted (68.6 [99.9]\u00a0mL vs. 196.7 [292.8] mL); values were comparable in paediatric subjects (2.1 [2.7] mL vs. 2.9 [2.7] mL). No serious or related adverse events (AEs) were reported during the perioperative period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perioperative administration of rVIII\u2010SingleChain effectively achieves and maintains haemostatic control in adult\/adolescent and paediatric subjects with haemophilia A undergoing surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70050","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:01:22Z","timestamp":1748336482000},"page":"634-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of rVIII\u2010SingleChain in Surgical Prophylaxis"],"prefix":"10.1111","volume":"31","author":[{"given":"Faraizah","family":"Abdul Karim","sequence":"first","affiliation":[{"name":"National Blood Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Mahlangu","sequence":"additional","affiliation":[{"name":"University of the Witwatersrand NHLS and Charlotte Maxeke Hospital  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-5049","authenticated-orcid":false,"given":"Claudia","family":"Djambas Khayat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hotel Dieu de France Saint Joseph University  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Ong","sequence":"additional","affiliation":[{"name":"Brokenshire Integrated  Davao City Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-4100","authenticated-orcid":false,"given":"Stephanie","family":"P'Ng","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1585-4100","authenticated-orcid":false,"given":"Johannes","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine University Hospital Bonn, Medical Faculty, University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Leissinger","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Pediatrics, and Pathology Tulane University School of Medicine  New Orleans Louisiana USA"},{"name":"Louisiana Center for Bleeding and Clotting Disorders  New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Lucas","sequence":"additional","affiliation":[{"name":"CSL Behring  King of Prussia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Suen","sequence":"additional","affiliation":[{"name":"CSL Behring  King of Prussia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Salazar","sequence":"additional","affiliation":[{"name":"CSL Behring  King of Prussia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7677-9896","authenticated-orcid":false,"given":"Ingrid","family":"Pabinger","sequence":"additional","affiliation":[{"name":"Clinical Division of Haematology and Haemostaseology Department of Medicine Medical University Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15256\/joc.2011.1.2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"issue":"9","key":"e_1_2_12_5_1","article-title":"Clotting Factor Concentrates Given to Prevent Bleeding and Bleeding\u2010Related Complications in People With Hemophilia A or B","author":"Iorio A.","year":"2011","journal-title":"Cochrane Database of Systematic Reviews 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