{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:03:45Z","timestamp":1774627425171,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilic arthropathy (HA) is characterized by recurrent intra\u2010articular bleeding leading to cartilage degeneration. Ferroptosis plays a critical role in this process. While IL\u201010 is known to inhibit apoptosis, its effect on ferroptosis remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate IL\u201010's role in chondrocyte ferroptosis in homophilic arthropathy via STAT3 signalling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cartilage samples from HA and OA patients were analyzed by TEM and Western blot for iron deposition and IL\u201010. ATDC5 chondrocytes were treated with FAC (iron overload), Erastin (ferroptosis inducer) and IL\u201010\u00b1STAT3 inhibitor (AG\u2010490). Cell viability assays, Western blotting, reactive oxygen species detection and immunofluorescent staining were performed. Viability, ROS and pathway proteins were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HA chondrocytes exhibited elevated mitochondrial iron deposition and reduced IL\u201010 versus OA controls. IL\u201010 suppressed ferroptosis with efficacy comparable to Fer\u20101, mechanistically dependent on STAT3 activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201010 suppresses ferroptosis in HA chondrocytes primarily via STAT3 signalling, providing theoretical support for its therapeutic potential for HA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70093","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:33:56Z","timestamp":1756136036000},"page":"1077-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interleukin\u201010 Mitigates Chondrocyte Ferroptosis Associated With Haemophilic Arthropathy via Modulation of the STAT3 Signalling Pathway"],"prefix":"10.1111","volume":"31","author":[{"given":"Fudong","family":"Luo","sequence":"first","affiliation":[{"name":"Graduate School of Bengbu Medical University  Bengbu Anhui China"},{"name":"Anhui No.2 Provincial People's Hospital  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[{"name":"Graduate School of Bengbu Medical University  Bengbu Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3561-9794","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School of Bengbu Medical University  Bengbu Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Anhui No.2 Provincial People's Hospital  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui No.2 Provincial People's Hospital  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defu","family":"Yu","sequence":"additional","affiliation":[{"name":"Graduate School of Bengbu Medical University  Bengbu Anhui China"},{"name":"School of Clinical Medicine Anhui Medical University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15444"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-1208"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245959"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14196"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.03.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01564-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04008-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05190-w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190418"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.05.003"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"139","article-title":"Interleukin\u201010 and Interleukin\u201010 Receptor in Human Osteoarthritic and Healthy Chondrocytes","volume":"19","author":"Iannone F.","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.06.016"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"593","article-title":"Coculture With Interleukin\u201010 Overexpressed Chondrocytes: A Cell Therapy Model to Ameliorate the Post\u2010Traumatic Osteoarthritis Development","volume":"35","author":"Yu L. 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