{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:41:20Z","timestamp":1773009680124,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilia treatment centres (HTCs) coordinate multidisciplinary care, yet the European HTC standards on which global accreditation systems really do not reflect the wide resource gradient found in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess HTC capacities across India and explore a tiered stratification model suited to diverse settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide, self\u2011administered survey (February\u00a02021\u2013April\u00a02022) was e\u2011mailed to all 291 HTCs registered with the Indian Association of Haemophilia and Allied Disorders. It captured infrastructure, laboratory capability and clinical services. Descriptive statistics and Spearman correlation were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety centres (30%) responded from 24 states\/UTs. Only 34% fulfilled European HTC (EHTC) criteria and 11% met comprehensive\u2011care (EHCCC) criteria; 55% were unclassified despite providing haemophilia care. Laboratory\u2011to\u2011clinical functionality showed a moderate correlation (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0 = \u00a00.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Twenty\u2011seven percent of centres operated without an onsite coagulation laboratory, whereas 40% lacked full\u2011time nurses and 60% lacked multidisciplinary teams. Factor VIII\/IX supplies were uninterrupted at 31% of sites; 38% offered prophylaxis to at least one patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Rigid European categories mask the stepwise growth of Indian HTCs. A four\u2011tier model\u2014anchored in predefined criteria for clinical and laboratory services could guide incremental upgrading while preserving patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70095","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T15:46:27Z","timestamp":1753803987000},"page":"973-980","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross\u2010Sectional Survey of Haemophilia Treatment Centres (HTCs) in India: Towards a Context\u2011Sensitive Stratification Model"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0820-7332","authenticated-orcid":false,"given":"M Joseph","family":"John","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Haemato\u2010Oncology &amp; Bone Marrow (Stem cell) Transplantations Christian Medical College  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-866X","authenticated-orcid":false,"given":"Chandrakala","family":"Shanmukhaiah","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Seth G.S.M.C and K.E.M. Hospital  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshirenla","family":"Aier","sequence":"additional","affiliation":[{"name":"IAHAD  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-8104","authenticated-orcid":false,"given":"Neeraj","family":"Sidharthan","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Amrita Institute of Medical Sciences Kochi  Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Saxena","sequence":"additional","affiliation":[{"name":"Path and Lab Medicine and Head of Hematopathology, Medanta  Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashikant","family":"Apte","sequence":"additional","affiliation":[{"name":"Department of Haematology &amp; Bone Marrow Transplant Unit Sahyadri Specialty Hospital  Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aby","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College  New Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soniya","family":"Nityanand","sequence":"additional","affiliation":[{"name":"King George Medical University  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecil","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplant St. John's Medical College Hospital  Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-7957","authenticated-orcid":false,"given":"Tulika","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Hematology All India Institute of Medical Sciences New Delhi  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplant St. John's Medical College Hospital  Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"World Federation of Hemophilia Report on the Annual Global Survey 2022","author":"World Federation of Hemophilia","year":"2023"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1976.03630070040012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01625.x"},{"issue":"3","key":"e_1_2_12_7_1","first-page":"s525","article-title":"The European Standards of Haemophilia Centres","volume":"12","author":"Giangrande P.","year":"2014","journal-title":"Blood Transfusion"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.6.616"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02928.x"},{"key":"e_1_2_12_10_1","volume-title":"Indian Association of Haemophilia and Allied Disorders\u2014IAHAD","year":"2020"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1999"},{"key":"e_1_2_12_12_1","volume-title":"Health Care System and Management: Health Care Organisation and Structure","author":"Goel S. 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