{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:27:15Z","timestamp":1783798035563,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Haemophilia is the most common inherited bleeding disorder. Dental management for people with haemophilia (PwH) (both A and B) is challenging, as dental procedures may initiate bleeding episodes that may be difficult to control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review aimed to evaluate and summarize the existing dental guidelines that are proposed from various agencies\/professional bodies, and so forth, for dental treatment procedures in PwH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic electronic search on databases like Scopus, Medline, EMBASE, CINAHL, ProQuest and Web of Science was performed. The parameters evaluated were (a) clotting factor replacement therapy employed, (b) haemostatic agents, both local and systemic therapy and (c) dental procedural and pharmacological considerations that are recommended before, during, and after dental treatment procedures for people with mild, moderate and severe haemophilia. The dental treatment procedures included all minor and major procedures, including surgical extraction of wisdom teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 11 guidelines were included for data extraction. The results indicated that all guidelines emphasized the importance of close collaboration among haematologists and dental professionals to ensure safe and effective dental treatment as a key component of comprehensive dental care. The various dental treatments (restorative, periodontal, orthodontic and prosthodontic treatments) and preventive aspects of oral health are detailed. Also, the amount of clotting factor replacement therapy for dental procedures, and pharmacological considerations recommended from the various professional organizations are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Well\u2010designed large\u2010scale research initiatives in dental management for PwH are necessary to understand the applicability and outcomes of such guidelines in clinical practice.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : REF\/2024\/01\/077096\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70104","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T09:10:08Z","timestamp":1755767408000},"page":"830-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dental Management for People With Congenital Haemophilia: A Systematic Review of the Existing Dental Recommendations"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1245-2314","authenticated-orcid":false,"given":"Mathangi","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Oral Medicine &amp; Radiology Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Haemophilia Treatment Centre Manipal Academy of Higher Education Kasturba Hospital  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-3413","authenticated-orcid":false,"given":"Sulochana","family":"Badagabettu","sequence":"additional","affiliation":[{"name":"Haemophilia Treatment Centre Manipal Academy of Higher Education Kasturba Hospital  Manipal Karnataka India"},{"name":"Department of Fundamentals of Nursing Manipal College of Nursing, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0967-5867","authenticated-orcid":false,"given":"Keerthilatha M.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Dental Surgery Sikkim Manipal Institute of Medical Sciences Sikkim Manipal University  Gangtok Sikkim India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-588X","authenticated-orcid":false,"given":"Judith","family":"Angelitta Noronha","sequence":"additional","affiliation":[{"name":"Department of Obstetrical and Gynaecological Nursing Manipal College of Nursing, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-9860","authenticated-orcid":false,"given":"Baby S.","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Child Health Nursing Manipal College of Nursing, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Ronald Sawers Haemophilia Centre Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Federation of Hemophilia World Federation of Hemophilia Report on the Annual Global Survey(World Federation of Hemophilia 2014)."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453312X13336169156492"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.13099"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102516.2012.02909.x"},{"issue":"6","key":"e_1_2_12_6_1","first-page":"56","article-title":"Dental Management of Patients With Inherited Bleeding Disorders: A Multidisciplinary Approach","volume":"65","author":"Abed H.","year":"2017","journal-title":"General Dentistry"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221114862"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14626"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2013.1097"},{"key":"e_1_2_12_10_1","first-page":"147","article-title":"Haemophilia and Von Willebrand Disease","volume":"153","author":"Growe G.","year":"1995","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.33882\/ClinicalDent.15.27514"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-018-1117-0"},{"key":"e_1_2_12_13_1","first-page":"575","article-title":"Principles of Treatment and Update of Recommendations for the Management of Haemophilia and Congenital Bleeding Disorders in Italy","volume":"12","author":"Rocino A.","year":"2014","journal-title":"Blood Transfusion"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2001.tb00272.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","unstructured":"A.BrewerandM. 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