{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:42:51Z","timestamp":1782949371006,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Glanzmann's thrombasthenia is a rare inherited platelet disorder characterized by a lack of platelet aggregation. Patients tend to be diagnosed in early childhood with treatment strategies involving a multifaceted approach to prevent and manage bleeding episodes. Unfortunately, there is currently no European consensus regarding the management of GT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This initiative aimed to gain an understanding of current clinical management of GT across Europe, with the aim of aligning best practice and improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors, on behalf of the EAHAD Glanzmann Working Group, administered an online survey of 57 questions to European haematologists currently involved in the management of patients with GT. The survey covered topics related to diagnosis, treatment access and selection, immunization, peri\u2010operative management and use of second\u2010line therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Responses reflected physician consensus around some topics, including peri\u2010operative treatment, use of recombinant factor VIIa, and concerns around antibody development. However, more varied responses were received on topics such as antibody screening (anti\u2010\n                      <jats:italic>\u03b1IIb\u03b23<\/jats:italic>\n                      antibodies screening conducted by \u226453% of respondents in all countries of interest except France), access to HLA\u2010matched platelet concentrates (none or limited for 55% of respondents) and duration of platelet transfusions for major surgery (13%\u201331% for 1, 2, 3 and 4 or more days of transfusions).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Establishing comprehensive guidelines to manage GT will enhance patient outcomes by ensuring patients receive high\u2010quality and effective care as well as standardize care across different healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70114","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:24:35Z","timestamp":1757600675000},"page":"1261-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["European Management of Glanzmann's Thrombasthenia: A Survey of Current Clinical Practice"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-8826","authenticated-orcid":false,"given":"Mathieu","family":"Fiore","sequence":"first","affiliation":[{"name":"Department of Haematology University Hospital of Bordeaux  Pessac France"},{"name":"Biology of Cardiovascular Disease Inserm U1034  Pessac France"},{"name":"French Reference Centre For Inherited Platelet Disorders University Hospital of Bordeaux  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Artoni","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8183","authenticated-orcid":false,"given":"Robert","family":"Klamroth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemophilia Treatment Center Vivantes Klinikum im Friedrichshain  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mathias","sequence":"additional","affiliation":[{"name":"Haemophilia Comprehensive Care Centre Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2762-6033","authenticated-orcid":false,"given":"Roger","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Department of Benign Hematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht and University Utrecht  Utrecht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-7805","authenticated-orcid":false,"given":"Roseline","family":"d'Oiron","sequence":"additional","affiliation":[{"name":"Centre De R\u00e9f\u00e9rence de L'h\u00e9mophilie Et Des Maladies H\u00e9morragiques Rares H\u00f4pital Bic\u00eatre AP\u2010HP; and INSERM H\u00e9mostase Inflammation Thrombose HITH U1176 Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EAHAD Glanzmann Thrombasthenia Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214239"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15087"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(02)00030-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-10"},{"issue":"8","key":"e_1_2_11_7_1","first-page":"647","article-title":"Glanzmann Thrombasthenia: A Clinicopathological Profile","volume":"26","author":"Iqbal I.","year":"2016","journal-title":"Journal of the College of Physicians and Surgeons\u2013Pakistan"},{"issue":"8","key":"e_1_2_11_8_1","first-page":"1038","article-title":"The International, Prospective Glanzmann Thrombasthenia Registry: Treatment and Outcomes in Surgical Intervention","volume":"100","author":"Poon M. C.","year":"2015","journal-title":"Haematologica"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S71319"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.01.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00767.x"},{"issue":"1","key":"e_1_2_11_12_1","first-page":"73","article-title":"Platelet Transfusion in a Patient Affected by Glanzmann's Thrombasthenia With Antibodies Against GPIIb\u2010IIIa","volume":"82","author":"Conte R.","year":"1997","journal-title":"Haematologica"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15728"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/107602960300900213"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"e_1_2_11_16_1","volume-title":"New York State Council on Human Blood and Transfusion Services: Guidelines for the Administration of Platelets","author":"Skerrett D. L.","year":"2012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502158"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1353393"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12898"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718373"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-12-08-0014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14559"},{"key":"e_1_2_11_23_1","unstructured":"\u201cEAHAD Glanzmann's Thrombasthenia Working Group \u201dEAHAD https:\/\/www.eahad.org\/about\u2010eahad\/glanzmann\u2010thrombasthenia\u2010working\u2010group\/."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb16249.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"issue":"8","key":"e_1_2_11_27_1","first-page":"1031","article-title":"The International, Prospective Glanzmann Thrombasthenia Registry: Treatment Modalities and Outcomes of Non\u2010Surgical Bleeding Episodes in Patients With Glanzmann Thrombasthenia","volume":"100","author":"Di Minno G.","year":"2015","journal-title":"Haematologica"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160754"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17824"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.227876"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:38:40Z","timestamp":1773002320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/hae.70114"],"URL":"https:\/\/doi.org\/10.1111\/hae.70114","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}