{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:29:49Z","timestamp":1773008989467,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Despite the well\u2010established lifelong impact of haemophilia on joint health, there remains a significant gap in our understanding of the developmental morphological changes that occur in the bones of haemophilic individuals. This study applied geometric morphometric measurement (GMM) to analyse age\u2010related morphological variations in the knee joints of haemophilia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study analysed 210 anteroposterior knee radiographs from 15 male haemophilia patients (ages 8\u201324), grouped into 8\u201315, 16\u201320, and 21\u201324 years. Twenty 2D bony landmarks were annotated by two raters (ICC\u00a0 = \u00a00.98). Generalized Procrustes analysis, principal component analysis, Procrustes ANOVA, and canonical variate analysis were performed. Associations with Pettersson score (PS) and Haemophilia Joint Health Score (HJHS) were examined via multivariate regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The diversity in morphology of knee joints among the first five principal components was 83%. Procrustes ANOVA indicated significant shape differences (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) among age groups. Furthermore, discriminant function analysis revealed the highest Mahalanobis distance (3.6212) between age group 1 and group 3, with significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Notable morphological alterations were identified, characterized by a medial displacement of the patella and a reduction in joint space.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study revealed significant age\u2010related morphological alterations in the knee joints of individuals with hemophilia. The position of the patella was identified as a key morphological marker, suggesting its potential utility for long\u2010term follow\u2010up and the development of targeted rehabilitation programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70133","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:13:53Z","timestamp":1759238033000},"page":"1283-1291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developmental Changes in Haemophilic Knee Joint Morphology: A Geometric Morphometric Study"],"prefix":"10.1111","volume":"31","author":[{"given":"Chieh\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng\u2010Ta","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Changhua Christian Hospital  Changhua Taiwan"},{"name":"Bachelor of Science in Senior Wellness and Sport Science Tunghai University  Taichung Taiwan"},{"name":"Master in Senior Health and Exercise Science Tunghai University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7789-2148","authenticated-orcid":false,"given":"Ming\u2010Ching","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hemophilia Treatment and Thrombosis Center, Changhua Christian Hospital  Changhua Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Li","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Changhua Christian Hospital  Changhua Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation School of Chinese Medicine, College of Chinese Medicine Department of Physical Therapy and Graduate Institute of Rehabilitation Science China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/HAE.14046"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102516.2008.01876.X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR\u201023\u20100101"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S343924"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102516.2010.02307.X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BLRE.2019.100642"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/HAE.14952"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/OS.14170"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJPA.24485"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FRI.2020.200390"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/CGA.12461"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041\u2010210X.12035"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ACTBIO.2021.06.013"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMPB.2023.107342"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0218542"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.25259\/JCIS_59_2022"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA067659"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ART.10769"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/NMETH.2089"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJPA.22846"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00167\u2010019\u201005802\u2010X"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCM.2016.02.012"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1755\u20100998.2010.02924.X"},{"issue":"6","key":"e_1_2_11_25_1","first-page":"820","article-title":"Biomechanics and Pathomechanics of the Patellofemoral Joint","volume":"11","author":"Loudon J. K.","year":"2016","journal-title":"International Journal of Sports Physical Therapy"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11420\u2010009\u20109140\u20109"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.20947"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM6070063"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/HAE.13472"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2519\/JOSPT.2003.33.11.639"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/HAE.12779"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/HAE.13858"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFMA.2021.07.017"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.RPTH.2024.102355"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:38:28Z","timestamp":1773002308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/hae.70133"],"URL":"https:\/\/doi.org\/10.1111\/hae.70133","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}