{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:48:47Z","timestamp":1791125327474,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Different strategies in prophylaxis for haemophilia among countries may affect long\u2010term outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study is to compare joint health in persons with severe haemophilia (PwSH) between Sweden and Greece, based on different approaches on prophylaxis initiation and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the PedNet Registry, which collects patient data prospectively, regarding measures on treatment and joint health using Haemophilia Joint Health Score (HJHS) and Haemophilia Early Arthropathy Detection with Ultrasound (HEAD\u2010US).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010one Swedish and 51 Greek PwSH (aged\u00a0\u2265\u00a010\u201318\u00a0years) were included. Swedish adolescents were diagnosed at earlier age (0.53 vs. 0.77\u00a0years in Greece,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). At prophylaxis initiation {earlier in Sweden (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01)}, dose regimens were more intense and escalation to full prophylaxis was reached earlier in Sweden. Median age at the last HEAD\u2010US\u00a0was 15.82 versus 14.07\u00a0years and at the last HJHS: 15.26 versus 15.86\u00a0years, for Sweden and Greece, respectively. Swedish and Greek PwSH had similar median total HJHS: 1.5 versus 1.0, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.38. Based on HEAD\u2010US, signs of synovitis were less frequent in Sweden for ankles (31.1% vs. 72.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), knees (11.1% vs. 44.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and elbows (8.9% vs. 27.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Bone\/cartilage abnormalities were also less frequent in Swedish patients (ankles: 11.1% vs. 30.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05, knees: 6.7% vs. 11.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.69, elbows: 8.9% vs. 19.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.20).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although adolescent PwSH clinically have good joint health in both countries, differences were detected by HEAD\u2010US, with earlier prophylaxis in Sweden being associated with better joint outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70140","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T08:41:18Z","timestamp":1760085678000},"page":"1209-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences Between Sweden and Greece in Joint Outcomes Assessed by Ultrasound in Adolescents With Severe Haemophilia on Prophylaxis: Data From the PedNet Registry"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-9823","authenticated-orcid":false,"given":"Aikaterini","family":"Michalopoulou","sequence":"first","affiliation":[{"name":"Haemophilia Centre\/Haemostasis and Thrombosis Unit Aghia Sophia Children's Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-0371","authenticated-orcid":false,"given":"Susanna","family":"Ranta","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden, and Childhood Cancer Research Unit, Karolinska, Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-8350","authenticated-orcid":false,"given":"Nadine G.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Center For Thrombosis and Haemostasis Sweden and Department of Clinical Sciences and Paediatrics Sk\u00e5ne University Hospital, Malm\u00f6, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-6613","authenticated-orcid":false,"given":"Kathelijn","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveld Kliniek, University Medical Center Utrecht, Utrecht, The Netherlands; PedNet Haemophilia Research Foundation  Baarn the Netherlands"},{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3521-1863","authenticated-orcid":false,"given":"Marloes","family":"de Kovel","sequence":"additional","affiliation":[{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsbeth","family":"de Boer\u2010Verdonk","sequence":"additional","affiliation":[{"name":"PedNet Haemophilia Research Foundation  Baarn the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-2686","authenticated-orcid":false,"given":"Jayashree","family":"Motwani","sequence":"additional","affiliation":[{"name":"Department of Haematology Haemophilia Comprehensive Care Centre, Birmingham Children's Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-2557","authenticated-orcid":false,"given":"Gili","family":"Kenet","sequence":"additional","affiliation":[{"name":"National Hemophilia Center Sheba, Tel Hashomer &amp; 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