{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:54:57Z","timestamp":1790571297732,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gene therapy (GT) represents a transformative development in the treatment of haemophilia, offering the potential for long\u2010lasting symptom control after a single administration. Although the scientific and medical aspects of this innovation have been widely studied, its psychological impact remains under\u2010addressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This paper explores the importance of providing continuous psychological support to individuals with haemophilia who are undergoing GT, emphasizing its necessity before, during, and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Persons living with haemophilia often experience a wide range of emotions, including hope, fear, anxiety, and uncertainty, particularly as they transition from managing a chronic condition to facing the possibility of long\u2010lasting therapeutic benefit and enduring freedom from regular treatment. Psychological support plays a pivotal role in preparing them to understand and cope with the profound shifts that GT entails. In the pre\u2010therapy stage, mental health professionals can help assess readiness, align expectations, and mitigate anxiety. During treatment, those with haemophilia may confront emotional stress related to the novelty, irreversibility, and physical effects of the procedure, including adverse reactions and the psychological consequences of steroid use. In the post\u2010treatment phase, emotional responses to treatment outcomes require careful management. Moreover, those who are ineligible for GT may experience emotional distress that also warrants psychological support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussions<\/jats:title>\n                    <jats:p>By recognizing these varied psychological dimensions, healthcare providers can implement comprehensive support strategies that enhance treatment adherence, emotional resilience, and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70165","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T13:23:57Z","timestamp":1763472237000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comprehensive Approach: Addressing Psychological Needs in Gene Therapy for Haemophilia"],"prefix":"10.1111","volume":"32","author":[{"given":"Aida","family":"Peyvandi","sequence":"first","affiliation":[{"name":"Department of Neurosciences and Mental Health Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Cutica","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato\u2010Oncology University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Garagiola","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre and Fondazione Luigi Villa  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre and Fondazione Luigi Villa  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102559"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15030698"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043021-033013"},{"issue":"12","key":"e_1_2_9_5_1","first-page":"2157","article-title":"Viral Vectors in Gene Replacement Therapy","volume":"88","author":"Minskaia E.","year":"2023","journal-title":"Biochem"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14378"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14440"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.17225\/jhp00174"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14188"},{"key":"e_1_2_9_10_1","article-title":"Clinical Trial \/Gene Therapy Psychosocial Template Contributors","volume":"12","author":"Tiggs C.","year":"2022","journal-title":"national hemophilia foundation"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S239810"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/26330040211047244"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327965PLI1104_01"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"196","article-title":"Gene Therapy of Hemophilia: Recommendations From the German , Austrian , and Swiss Society for Thrombosis and Haemostasis Research ( GTH )","volume":"43","author":"Miesbach W.","year":"2023","journal-title":"Hamostaseologie"},{"key":"e_1_2_9_15_1","volume-title":"Stress, Appraisal, and Coping","author":"LazarSus R. 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