{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:54:58Z","timestamp":1790571298356,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Haemophilic arthropathy (HA) is a common complication of haemophilia, characterized by progressive joint degeneration due to recurrent bleeding. Iron overload from erythrocyte lysis is thought to play a key role in HA pathogenesis, but its molecular basis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed data\u2010independent acquisition (DIA) proteomics on synovial tissues from HA, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. Bioinformatics analyses (GO, KEGG, PPI) were used to identify iron\u2010related differentially expressed proteins (DEPs), and selected candidates were validated by Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to OA and RA, HA synovium exhibited distinct expression patterns enriched in iron metabolism\u2013related pathways, including ferroptosis and porphyrin metabolism. Key DEP such as FTH1 was upregulated, while SLC39A14 was downregulated. PPI analysis highlighted hub proteins involved in iron homeostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies a unique iron overload\u2013related proteomic signature in HA synovium, suggesting the potential biomarkers in disease progression. These findings provide novel molecular insights and potential targets for early HA intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70171","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:50:06Z","timestamp":1764348606000},"page":"255-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of Iron Overload\u2013Associated Biomarkers in the Synovium of Haemophilic Arthropathy"],"prefix":"10.1111","volume":"32","author":[{"given":"Yi","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Anhui No.2 Provincial People's Hospital  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Anhui No.2 Provincial People's Hospital  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Anhui No.2 Provincial People's Hospital  Hefei Anhui China"},{"name":"Graduate School of Bengbu Medical University  Bengbu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13405-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02139-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.11.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121172"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000002628"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167058"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2196\/16631"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200207000-00007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3549-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.01.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.07.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.05.017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0874"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120370"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-024-01520-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12101"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14417"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0390"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4231"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000002628"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2932696"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13518"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.12.013"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2021.04.005"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109422"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101481"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B3.0800540"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13049"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05695-9"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512242"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16497"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.05.017"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-021-00327-z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14651"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg4302"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.05.011"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01439-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01221-3"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abn8017"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155212"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.70171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.70171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:55:44Z","timestamp":1790567744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.70171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/hae.70171"],"URL":"https:\/\/doi.org\/10.1111\/hae.70171","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-08-23","order":0,"name"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