{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:11:27Z","timestamp":1773418287784,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Medical claims are increasingly used to study haemophilia, a rare and costly X\u2010linked congenital bleeding disorder. However, there is no standard method to identify people with haemophilia A (PwHA) in medical claims, and it is unknown how existing approaches influence the cohort selected. Thus, this study evaluates cohort characteristics across three existing methods to identify PwHA in Medicare claims data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medicare claims data (2000\u20132020) were used to identify PwHA using three approaches: Cohort A: A historic validated algorithm relying on eight diagnosis, treatment, and health services variables; Cohort B: receipt of haemophilia treatment, and Cohort C: generic health services definition of \u22652 haemophilia diagnosis codes 30 days apart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five thousand six hundred and two unique beneficiaries were identified as having haemophilia A across the three methods. Three\u2010quarters of beneficiaries (76.7%) were in Cohort C (diagnosis) alone, 16.1% and 3.7% were in Cohorts A (algorithm) and B (treatment), respectively. Fewer than 5% were in two or more cohorts. Over 85% of those in Cohorts A (88.8%) and B (85.2%) were male and received haemophilia treatment. In Cohort C, less than half (42.9%) were male, and &lt;10% had haemophilia treatments recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, we compared three methods to identify PwHA in claims. Generic diagnosis coding may overcount those tested for haemophilia but ultimately not diagnosed, whereas historical algorithms and treatment\u2010based selection may underrepresent those with non\u2010severe haemophilia, including females. Contemporary validated algorithms are needed to improve the utility of claims for haemophilia research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70184","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:31:02Z","timestamp":1766413862000},"page":"410-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Approaches to Identify People With Haemophilia With Medicare Claims Data"],"prefix":"10.1111","volume":"32","author":[{"given":"Stacey A.","family":"Fedewa","sequence":"first","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler W.","family":"Buckner","sequence":"additional","affiliation":[{"name":"Hemophilia and Thrombosis Center University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Cafuir","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Sidonio","sequence":"additional","affiliation":[{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies at the University of\u00a0Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Kempton","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Hemophilia of Georgia Center for Bleeding &amp; Clotting Disorders of Emory Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15182"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14859"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15189"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003424"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2015.06.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2196922"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.02.107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24220"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13847"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2022.2102779"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2023.2198207"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2134"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2196\/publichealth.6720"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0033354919839072"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.03.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2024.23328"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13981"},{"key":"e_1_2_9_20_1","unstructured":"Centers for Disease Control. 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