{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:11:12Z","timestamp":1773418272339,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glanzmann thrombasthenia (GT) is an inherited platelet disorder resulting in severely reduced platelet aggregation and increased bleeding tendency. Pregnancy and childbirth in women with GT present significant challenges for both mother and child.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to present the current clinical practices in pregnancy and childbirth in GT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A survey on the management of the preconception phase, pregnancy and childbirth in women with GT was conducted by the European Association of Haemophilia and Allied Disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010seven responses from 18 countries were analysed. Almost all respondents recommended multidisciplinary preconception counselling, though 11% lack access to obstetrics and gynaecology services focused on bleeding disorders. Delay in conceiving was reported by 62%. Ninety\u2010one percent of respondents indicated that they would screen for platelet alloimmunisation; however, the timing of screening varied. The recommended treatment to prevent postpartum haemorrhage (PPH) most often comprised tranexamic acid (TXA) and recombinant activated factor VII (rFVIIa) (25%) or TXA, rFVIIa and platelet transfusion (22%). The latter combination was also the most frequently recommended treatment to have on standby. Seventy\u2010five percent would advise a mode of delivery as per obstetric indication and 69% would recommend to avoid neuraxial anaesthesia. Half of the respondents would add pharmacological thromboprophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is general consensus on the importance of preconception counselling, the screening for platelet alloimmunisation and the preferred mode of delivery. Opinions regarding the treatment of PPH and the use of thromboprophylaxis vary. The next step is to improve guideline implementation in daily practice while working toward an international consensus\u2010based guideline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70186","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:12:26Z","timestamp":1765962746000},"page":"554-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["International Practices in Managing Preconception, Pregnancy and Childbirth in Women With Glanzmann Thrombasthenia: A Survey From the European Association of Haemophilia and Allied Disorders (EAHAD)"],"prefix":"10.1111","volume":"32","author":[{"given":"Karlijn H. G.","family":"Rutten","sequence":"first","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger E. G.","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-7805","authenticated-orcid":false,"given":"Roseline","family":"d'Oiron","sequence":"additional","affiliation":[{"name":"Centre De R\u00e9f\u00e9rence de L'h\u00e9mophilie Et Des Maladies H\u00e9morragiques Rares H\u00f4pital Bic\u00eatre APHP  Le Kremlin\u2010Bic\u00eatre France"},{"name":"INSERM H\u00e9mostase Inflammation Thrombose HITH U1176 Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-8826","authenticated-orcid":false,"given":"Mathieu","family":"Fiore","sequence":"additional","affiliation":[{"name":"Haematology Laboratory Reference Center for Inherited Platelet Disorders University Hospital of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-1317","authenticated-orcid":false,"given":"Giancarlo","family":"Castaman","sequence":"additional","affiliation":[{"name":"Department of Heart Lungs Center for Bleeding Disorders and Coagulation and Vessels Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Gomez","sequence":"additional","affiliation":[{"name":"Haemophilia Centre and Thrombosis Unit The Royal Free NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-0469","authenticated-orcid":false,"given":"Mary","family":"Mathias","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4216","authenticated-orcid":false,"given":"Michelle","family":"Lavin","sequence":"additional","affiliation":[{"name":"National Coagulation Centre St. James's Hospital  Dublin Ireland"},{"name":"Irish Centre for Vascular Biology School of Pharmacy and Biomolecular Sciences RCSI  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Elfvinge","sequence":"additional","affiliation":[{"name":"Department of Haematology Karolinska University  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-1006","authenticated-orcid":false,"given":"Rezan Abdul","family":"Kadir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology and Katherine Dormandy Haemophilia Centre and Thrombosis Unit The Royal Free NHS Foundation Trust and Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin P. M.","family":"van Galen","sequence":"additional","affiliation":[{"name":"Center For Benign Haematology Thrombosis and Haemostasis Van Creveldkliniek University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Glanzmann Thrombasthenia and Women and Girls with Bleeding Disorders Working Groups of the EAHAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-10"},{"issue":"7","key":"e_1_2_10_3_1","first-page":"1383","article-title":"Glanzmann's Thrombasthenia: The Spectrum of Clinical Disease","volume":"75","author":"George J. 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