{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:11:05Z","timestamp":1773418265214,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Coagulation testing in haemophilia A is limited by the scarcity of testing facilities capable of performing relevant assays. This issue incentivized the development of the EnzySystem for haemophilia A, a near\u2010patient testing platform aimed to measure Factor VIII activity and thrombin generation simultaneously within 1\u00a0h from 100\u00a0\u00b5L of whole blood. Involving end\u2010users throughout the development ensures innovations are well\u2010suited to meet real\u2010world clinical needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To determine EnzySystem's acceptance, envisioned use scenarios and determinants for implementation according to healthcare providers (HCPs) and persons with haemophilia A and caregivers (PwHA\/C).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010centre, cross\u2010sectional mixed methods study was performed involving two participant groups. The first involved 36 PwHA\/C. The second group comprised five advanced practice providers, eight nurses, four pharmacists and five haematologists, all involved in haemophilia A care. The participants\u2019 attitudes and preferences toward the EnzySystem for haemophilia A were assessed through questionnaires and focus groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acceptability was high for both groups. The platform was considered suitable for use in various scenarios, but self\u2010testing at home was prioritized by PwHA\/C. HCPs placed equal emphasis on near\u2010patient testing in clinic to address issues with current test accessibility and turnaround time. For all potential use scenarios, demonstrating assay accuracy was a non\u2010negotiable prerequisite. The turnaround time and accessibility were identified as other key attributes by both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this study support the further development of the EnzySystem for haemophilia A and highlight barriers that should be addressed to facilitate implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.70191","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T09:03:06Z","timestamp":1765962186000},"page":"481-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acceptability and Determinants for Implementation of the EnzySystem, a Novel Near\u2010Patient Testing Platform for Haemophilia A"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-9151","authenticated-orcid":false,"given":"Aernoud P.","family":"Bavinck","sequence":"first","affiliation":[{"name":"Department of Hematology Radboud University Medical Centre  Nijmegen the Netherlands"},{"name":"Enzyre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1272-1307","authenticated-orcid":false,"given":"Kyle","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Innovative Hematology Indiana Hemophilia and Thrombosis Center  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"van Engelshoven","sequence":"additional","affiliation":[{"name":"Enzyre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-6639","authenticated-orcid":false,"given":"Monique G.","family":"van Lier","sequence":"additional","affiliation":[{"name":"Teledyne Healthcare  Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-9143","authenticated-orcid":false,"given":"Tanja","family":"Hamacher","sequence":"additional","affiliation":[{"name":"Holland Innovative  Eindhoven the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-2072","authenticated-orcid":false,"given":"Nicole M. A.","family":"Blijlevens","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-7159","authenticated-orcid":false,"given":"Amy","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Innovative Hematology Indiana Hemophilia and Thrombosis Center  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-2829","authenticated-orcid":false,"given":"Saskia E. 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